Lu AA47070
Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade.
For research use only. We do not sell to patients.
- CAS No.: 913842-25-8
- Formula: C17H20F2N3O6PS
- Molecular Weight:463.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Pharmacokinetic Parameters of Lu AA47070 in Sprague-Dawley rats[1].
| Compd | dose （mg/kg） | AUC(ng*h/L) | Tmax (h) | Cmax (ng/mL) | F (%) |
| 32 | 1.5 | 2.9±0.7 | 0.5±0.1 | 869±68 | 55±13 |
| 32 | 15 | 35±3.0 | 0.4±0.2 | 6413±281 | 66±6 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague Dawley rats[2]
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Dosage:3.75, 7.5, 15, 30 mg/kg
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Administration:I.p.
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Result:Reversed the tremulous jaw movements, catalepsy, and locomotor suppression induced by subchronic administration of the D2 antagonist pimozide (1.0 mg/kg IP).
Chemical Information
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CAS No. 913842-25-8
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Molecular Weight 463.39
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Formula C17H20F2N3O6PS
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SMILES
O=P(O)(O)OCN1C=CS/C1=N\C(C2=CC(F)=C(NC(CC(C)(C)C)=O)C(F)=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Lu AA47070 Related Classifications
HY-14408 Related Classifications
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