913842-25-8
913842-25-8
Chemical Structure
Lu AA47070
- CAS No.: 913842-25-8
- Formula:C17H20F2N3O6PS
- Molecular Weight:463.39
IUPAC Name: (Z)-(2-((4-(3,3-dimethylbutanamido)-3,5-difluorobenzoyl)imino)thiazol-3(2H)-yl)methyl dihydrogen phosphate
InChIKey: MSWIQSFUBYCFJE-PGMHBOJBSA-N
SMILES: O=P(O)(O)OCN1C=CS/C1=N\C(C2=CC(F)=C(NC(CC(C)(C)C)=O)C(F)=C2)=O
Biological Activity: Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade[1][2].
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Lu AA47070 | Lu AA47070 is a phosphonooxymethylene prodrug of a potent and selective Adenosine A2A receptor antagonist. Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. | |||||||||||||||||||||
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References
- [1]. Discovery of Phosphoric Acid Mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} Ester (Lu AA47070): A Phosphonooxymethylene Prodrug of a Potent and Selective hA2A Receptor Antagonist J. Med. Chem., Article ASAP DOI: 10.1021/jm1008659 Publication Date (Web): January 6, 2011
- [2]. Collins LE, et al. The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade. Pharmacol Biochem Behav. 2012 Jan;100(3):498-505. [Content Brief]
Keywords
