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NF-κB-IN-1

3 Cited Publications
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Based on 3 publication(s) in Google Scholar

NF-κB-IN-1, a 4-arylidene crucumin analogue, is a potent NF-κB signaling pathway inhibitor. NF-κB-IN-1 directly inhibits IKK to block NF-κB activation. NF-κB-IN-1 effectively inhibits the viability of lung cancer cells and attenuates the clonogenic activity of A549 cells.

For research use only. We do not sell to patients.

  • Purity: 98.37%
  • CAS No.: 1227098-15-8
  • Formula: C31H30O8
  • Molecular Weight:530.57
  • Storage:
    Powder   -20°C, 3 years ; In solvent   -80°C, 6 months , -20°C, 1 month
  • NF-κB-IN-1 Chemical Structure
  • Experimental Validation Results for NF-κB-IN-1
  • Experimental Validation Results for NF-κB-IN-1
  • Experimental Validation Results for NF-κB-IN-1
  • Experimental Validation Results for NF-κB-IN-1
  • Experimental Validation Results for NF-κB-IN-1
  • NF-κB-IN-1 Chemical Structure
    NF-κB-IN-1 Chemical Structure
  • Experimental Validation Results for NF-κB-IN-1
  • Experimental Validation Results for NF-κB-IN-1
  • Experimental Validation Results for NF-κB-IN-1
  • Experimental Validation Results for NF-κB-IN-1
  • Experimental Validation Results for NF-κB-IN-1
CAS No.: 1227098-15-8
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  • NF-κB-IN-1 Chemical Structure
    NF-κB-IN-1 Chemical Structure
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  • 1/16

    NF-κB-IN-1 purchased from MedChemExpress. Usage Cited in: Adv Biol (Weinh). 2025 Jun 4:e00761. [Abstract]

    Customer Validation
     Macrophages were pretreated with inhibitors of the ERK (HY‐112287; ERK1/2 inhibitor 1), JNK (HY‐12041; SP600125), p38 MAPK (HY‐12839; p38 MAPK-IN-1), and p65 NF‐kB (HY‐138537; NF-κB-IN-1) pathways prior to incubation with pyroptotic‐CM for 4 h.The MET formation by macrophages was evaluated with SYTOX Green staining and detected by flow cytometry.

  • 1/16

    NF-κB-IN-1 purchased from MedChemExpress. Usage Cited in: Adv Biol (Weinh). 2025 Jun 4:e00761. [Abstract]

    Customer Validation
     Macrophages were pretreated with inhibitors of the ERK (HY‐112287; ERK1/2 inhibitor 1), JNK (HY‐12041; SP600125), p38 MAPK (HY‐12839; p38 MAPK-IN-1), and p65 NF‐kB (HY‐138537; NF-κB-IN-1) pathways prior to incubation with pyroptotic‐CM for 4 h. The p‐p38 and p‐p65 levels in macrophages were measured by western blotting.

  • 1/16

    NF-κB-IN-1 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 May 1;21(1):86. [Abstract]

    Customer Validation
     Neutrophils were pretreated with inhibitors of the ERK (HY-112287;ERK1/2 inhibitor 1), p38 MAPK (HY-12839; p38 MAPK-IN-1), and p65 NF-кB (HY-138537; NF-κB-IN-1) pathways prior to incubation with hypoxic-CM from GC cells. The protein levels of p-ERK, p-p38, and p-p65 in neutrophils were measured by western blotting.

  • 1/16

    NF-κB-IN-1 purchased from MedChemExpress. Usage Cited in: Cell Commun Signal. 2023 May 1;21(1):86. [Abstract]

    Customer Validation
     Neutrophils were pretreated with inhibitors of the ERK (HY-112287;ERK1/2 inhibitor 1), p38 MAPK (HY-12839; p38 MAPK-IN-1), and p65 NF-кB (HY-138537; NF-κB-IN-1) pathways prior to incubation with hypoxic-CM from GC cells. The NET formation by neutrophils was evaluated with MPO and citH3 staining. Magnification: 20 × . Scale bars: 50 μm.

  • 1/16

    NF-κB-IN-1 purchased from MedChemExpress. Usage Cited in: Cancer Med. 2023 Jul;12(14):15676-15690. [Abstract]

    Customer Validation
     IKK‐inhibitor (HY‐138537; NF-κB-IN-1) could block NF‐kB activation and decrease the downstream proteins HLA‐A/B/C and PD‐L1.

  • NF-κB-IN-1