BNS-22
Based on 1 Customer Validation
BNS-22 is a DNA topoisomerase II (TOP2) catalytic inhibitor with the IC50 values of 2.8 μM and 0.42 μM for human TOP2α and TOP2β, respectively. BNS-22 induces abnormal division and has anti-proliferative activity.
For research use only. We do not sell to patients.
- Purity: 99.50%
- CAS No.: 1151668-24-4
- Formula: C24H25NO5
- Molecular Weight:407.46
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Topoisomerase Isoforms
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Biological Activity
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topoisomerase II alpha 2.8 μM (IC50, in human) |
topoisomerase II beta 0.42 μM (IC50, in human) |
BNS-22 (0-30 μM, 24-48 h) can inhibit cell growth and influence on cell cycle progression of the human cervical epidermoid carcinoma cell line HeLa in a dose-dependent manner[1].
BNS-22 (0-30 μM, 0-6 h) does not induce DNA damage and has an antagonistic effect on TOP2 toxin-mediated DNA damage[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cell lines
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Concentration:0-30 μM
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Incubation Time:24 h, 48 h
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Result:Inhibited cell growth with the IC50 value of 4.9 μM after 24 hours and 1.0 μM after 48 hours.
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Cell Line:HeLa cell lines
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Concentration:0-30 μM
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Incubation Time:24 h
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Result:Increased number of cells in G2/M phase.
Disrupted mitotic spindle formation and induced polyploid cell formation at 3 μM.
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Cell Line:HeLa cell lines
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Concentration:0-30 μM
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Incubation Time:0, 30 min, 1 h, 2 h, 4 h, 6 h
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Result:Decreased etoposide-induced γ-H2AX expression and decreased total cellular TOP2β levels, but not TOP2α levels.
Chemical Information
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CAS No. 1151668-24-4
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Appearance Solid
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Molecular Weight 407.46
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Formula C24H25NO5
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Color White to off-white
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SMILES
O=C1C=C(CCC)C2=C(OC)C=C(OC)C(C(N3CCCC4=C3C=CC=C4)=O)=C2O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (122.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4542 mL | 12.2711 mL | 24.5423 mL | 61.3557 mL |
| 5 mM | 0.4908 mL | 2.4542 mL | 4.9085 mL | 12.2711 mL | |
| 10 mM | 0.2454 mL | 1.2271 mL | 2.4542 mL | 6.1356 mL | |
| 15 mM | 0.1636 mL | 0.8181 mL | 1.6362 mL | 4.0904 mL | |
| 20 mM | 0.1227 mL | 0.6136 mL | 1.2271 mL | 3.0678 mL | |
| 25 mM | 0.0982 mL | 0.4908 mL | 0.9817 mL | 2.4542 mL | |
| 30 mM | 0.0818 mL | 0.4090 mL | 0.8181 mL | 2.0452 mL | |
| 40 mM | 0.0614 mL | 0.3068 mL | 0.6136 mL | 1.5339 mL | |
| 50 mM | 0.0491 mL | 0.2454 mL | 0.4908 mL | 1.2271 mL | |
| 60 mM | 0.0409 mL | 0.2045 mL | 0.4090 mL | 1.0226 mL | |
| 80 mM | 0.0307 mL | 0.1534 mL | 0.3068 mL | 0.7669 mL | |
| 100 mM | 0.0245 mL | 0.1227 mL | 0.2454 mL | 0.6136 mL |
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