258 Results for "

phospholipase-d

" in MedChemExpress (MCE) Product Catalog:
Products (258)

258 Results for "phospholipase-d" in MCE Product Catalog:

100
U-73122
U-73122
0 Images
100 Publications Verification
Cat. No.: HY-13419
CAS No.: 112648-68-7
Purity:  98.41%
Target:  

Phospholipase Lipoxygenase Ferroptosis

Research Areas:  

Inflammation/Immunology

U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50of 1-2.1 µM for PLC.
68
Neomycin sulfate
Neomycin sulfate
0 Images
68 Cited Publications
Cat. No.: HY-B0470
CAS No.: 1405-10-3
Category:  

Disease Research Antibacterial Other Antibiotics Infection Microorganisms Antibiotics Animal Husbandry Mammalian Cell Culture Anticancer Disease Research Fields

Target:  

Environmental Pollutants Antibiotic Phospholipase Bacterial

Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate is a known phospholipase C (PLC) inhibitor. Neomycin sulfate potently inhibits both the nuclear translocation of angiogenin and angiogenin-induced cell proliferation and angiogenesis. Neomycin sulfate inhibits IP3-mediated Ca 2+ release, MgATP-dependent Ca 2+ uptake, and electrical excitation-evoked skeletal muscle Ca 2+ transients. Neomycin sulfate depletes gut microbiota in specific mouse models, causes hearing impairment, and kidney damage with prolonged exposure. Neomycin sulfate can be used for the research of cancer .
36
BAPTA
BAPTA
0 Images
36 Cited Publications
Cat. No.: HY-100168
CAS No.: 85233-19-8
Purity:  98.10%
BAPTA is a selective and cell-impermeant chelator for calcium. BAPTA has high selectivity against magnesium and calcium. BAPTA can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators .
36
BAPTA tetrasodium
BAPTA tetrasodium
0 Images
36 Cited Publications
Cat. No.: HY-100168A
CAS No.: 126824-24-6
Purity:  99.70%
Target:  

Phospholipase

Research Areas:  

Others

BAPTA tetrasodium is a selective and cell-impermeant chelator for calcium. BAPTA tetrasodium has high selectivity against magnesium and calcium. BAPTA can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators .
36
BAPTA tetrapotassium
BAPTA tetrapotassium
0 Images
36 Cited Publications
Cat. No.: HY-100168B
CAS No.: 73630-08-7
Purity:  99.45%
BAPTA tetrapotassium is a selective and cell-impermeant chelator for calcium. BAPTA has high selectivity against magnesium and calcium. BAPTA tetrapotassium can also inhibit phospholipase C activity independently of their role as Ca 2+ chelators .
9
Varespladib
Varespladib
0 Images
9 Cited Publications
Cat. No.: HY-13402
CAS No.: 172732-68-2
Purity:  99.23%
Synonyms: LY315920
Target:  

Phospholipase

Research Areas:  

Inflammation/Immunology

Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .
9
Varespladib sodium
Varespladib sodium
0 Images
9 Cited Publications
Cat. No.: HY-13402A
CAS No.: 172733-42-5
Purity:  ≥98.0%
Synonyms: LY315920 sodium
Target:  

Phospholipase

Research Areas:  

Inflammation/Immunology

Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .
8
CAY10650
CAY10650
0 Images
8 Cited Publications
Cat. No.: HY-10801
CAS No.: 1233706-88-1
Purity:  ≥98.0%
Target:  

Phospholipase

Research Areas:  

Inflammation/Immunology

CAY10650 is a highly potent cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 12 nM. CAY10650 suppresses lipid droplets formation and PGE2 secretion .
8
D609
D609
0 Images
8 Cited Publications
Cat. No.: HY-70072
CAS No.: 83373-60-8
Target:  

Phospholipase

Research Areas:  

Infection Inflammation/Immunology Cancer

D609, an antitumoural xanthate, is a specific and competitive phosphatidyl choline-specific phospholipase C (PC-PLC) inhibitor with a Ki of 6.4 μM. D609 is an antioxidative protector and has antiviral and anti-inflammatory activity .
8
m-3M3FBS
m-3M3FBS
0 Images
8 Cited Publications
Cat. No.: HY-19619
CAS No.: 200933-14-8
Target:  

Phospholipase Apoptosis

Research Areas:  

Cancer

m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis .
7
(E/Z)-BML264
(E/Z)-BML264
0 Images
7 Cited Publications
Cat. No.: HY-118628
CAS No.: 110683-10-8
Purity:  99.63%
Synonyms: N-(p-Amylcinnamoyl) anthranilic acid; ACA
Target:  

Phospholipase TRP Channel

Research Areas:  

Cardiovascular Disease

(E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker . (E/Z)-BML264 (N-(p-amylcinnamoyl) Anthranilic Acid) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia .
7
U-73343
U-73343
0 Images
7 Cited Publications
Cat. No.: HY-108630
CAS No.: 142878-12-4
Purity:  99.31%
Target:  

Phospholipase

Research Areas:  

Others

U-73343, works as a protonophore, is an inactive analog of U-73122 and can be used as a negative control. U-73343 dose-dependently inhibits acid secretion irrespective of the stimulant. U-73122 is a phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with an IC50 of 1-2.1 μM for PLC .
5
FIPI
FIPI
0 Images
5 Cited Publications
Cat. No.: HY-12807
CAS No.: 939055-18-2
Purity:  98.00%
Synonyms: 5-Fluoro-2-indolyl deschlorohalopemide
Target:  

Phospholipase

Research Areas:  

Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer

FIPI is a phospholipase D (PLD) inhibitor with an IC50 for PLD1 and PLD2 of about 25 nM. FIPI regulates cytoskeletal recombination, cell diffusion and chemotaxis. FIPI can be used in cancer research. In addition, FIPI can enhance the secretion and aggregation of platelet dense particles, inhibit thrombosis, reduce ischemic stroke infarct volume and improve nerve function .
5
Compound 48/80
Compound 48/80
0 Images
5 Cited Publications
Cat. No.: HY-115768
CAS No.: 94724-12-6
Purity:  99.98%
Synonyms: Poly-p-methoxyphenethylmethylamine
Target:  

Phospholipase

Research Areas:  

Neurological Disease Cancer

Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways .
5
Compound 48/80 trihydrochloride
Compound 48/80 trihydrochloride
0 Images
5 Cited Publications
Cat. No.: HY-130592
CAS No.: 848035-21-2
Purity:  99.95%
Synonyms: C48/80 trihydrochloride
Target:  

Phospholipase

Research Areas:  

Neurological Disease

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
4
DHPG
DHPG
0 Images
4 Cited Publications
Cat. No.: HY-12598A
CAS No.: 146255-66-5
Purity:  99.65%
Synonyms: (RS)-3,5-DHPG
Target:  

mGluR

Research Areas:  

Neurological Disease

DHPG is the agonist for mGluR 1/5 (EC50 for mGluR 1 is 60 nM) that activates the phospholipase C (PLC) pathway, and leads ultimately to the activation of protein kinase C (PKC) .
4
Pyrrophenone
Pyrrophenone
0 Images
4 Cited Publications
Cat. No.: HY-111376
CAS No.: 341973-06-6
Purity:  99.60%
Target:  

Phospholipase

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

Pyrrophenone is a potent and specific cytosolic phospholipase A2α (cPLA2α) inhibitor with an IC50 value of 4.2 nM .
4
3-Nitrocoumarin
3-Nitrocoumarin
0 Images
4 Cited Publications
Cat. No.: HY-111919
CAS No.: 28448-04-6
Purity:  100.0%
Target:  

Phospholipase Fungal

Research Areas:  

Infection

3-Nitrocoumarin is an inhibitor for phospholipase C that blocks the generation of inositol triphosphate (IP3), thereby affecting the calcium signaling pathway .
4
AACOCF3
AACOCF3
0 Images
4 Cited Publications
Cat. No.: HY-108611
CAS No.: 149301-79-1
Purity:  ≥99.0%
Synonyms: Arachidonyl trifluoromethyl ketone
Target:  

Phospholipase

Research Areas:  

Cardiovascular Disease

AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeant trifluoromethyl ketone analog of arachidonic acid. AACOCF3 is a potent and selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). AACOCF3 blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets. AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets. AACOCF3 has the potential for the research of cardiovascular disease .
3
LEI-401
LEI-401
0 Images
3 Cited Publications
Cat. No.: HY-131181
CAS No.: 2393840-15-6
Purity:  99.73%
Target:  

Phospholipase

Research Areas:  

Neurological Disease

LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. LEI-401 modulates emotional behavior in mice .
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