2. Apoptosis Cell Cycle/DNA Damage Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis DNA/RNA Synthesis Reactive Oxygen Species (ROS) Keap1-Nrf2
  4. QD 232

QD 232 is a quinazolinedione-based ROS inducer and an apoptosis inducer with cytotoxicity and redox regulatory activity. QD 232 promotes ROS accumulation, activates the NRF2-mediated oxidative stress response and unfolded protein response pathways, and upregulates downstream antioxidant and stress response genes. QD 232 inhibits mtDNA transcription driven by HSP2 and LSP promoters, and impairs mitochondrial oxidative phosphorylation function. QD 232 induces apoptosis of pancreatic ductal adenocarcinoma cells and exerts cytotoxicity against gemcitabine (HY-17026)-resistant pancreatic ductal adenocarcinoma cells. QD 232 delays tumor growth in a mouse pancreatic cancer xenograft model.

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QD 232

QD 232 Chemical Structure

CAS No. : 1527467-32-8

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QD 232 Related Antibodies

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Description

QD 232 is a quinazolinedione-based ROS inducer and an apoptosis inducer with cytotoxicity and redox regulatory activity. QD 232 promotes ROS accumulation, activates the NRF2-mediated oxidative stress response and unfolded protein response pathways, and upregulates downstream antioxidant and stress response genes. QD 232 inhibits mtDNA transcription driven by HSP2 and LSP promoters, and impairs mitochondrial oxidative phosphorylation function. QD 232 induces apoptosis of pancreatic ductal adenocarcinoma cells and exerts cytotoxicity against gemcitabine (HY-17026)-resistant pancreatic ductal adenocarcinoma cells. QD 232 delays tumor growth in a mouse pancreatic cancer xenograft model[1].

In Vitro

QD 232 (30 nM - 10 μM; 72 h) inhibits proliferation of MIA PaCa-2, Panc-1, and BxPC-3 PDAC cell lines with IC50 values of 2.3 μM, 0.9 μM, and 5.2 μM, respectively[1].
QD 232 (30 nM - 10 μM; 72 h) inhibits proliferation of gemcitabine-resistant MIA PaCa-2-GR cells and normal HPDE pancreatic cells with IC50 values of 3.6 μM and 4.5 μM, respectively[1].
QD 232 (30 nM - 10 μM; 72 h) has its proliferation inhibitory effect in MIA PaCa-2 cells attenuated by pretreatment with 5 mM NAC (HY-B0215)[1].
QD 232 treatment induces time-dependent increases in CHOP and GRP78 protein levels in MIA PaCa-2, Panc-1, and BxPC-3 cells, upregulates HO-1 protein in MIA PaCa-2 and BxPC-3 cells, and does not induce NQO1 protein in MIA PaCa-2 and BxPC-3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

QD 232 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MIA PaCa-2, Panc-1, BxPC-3 pancreatic ductal adenocarcinoma (PDAC) cell lines
Concentration: 30 nM - 10 μM
Incubation Time: 72 h
Result: Inhibited cell proliferation with IC50 values of 2.3 μM in MIA PaCa-2 cells, 0.9 μM in Panc-1 cells, and 5.2 μM in BxPC-3 cells.

Cell Proliferation Assay[1]

Cell Line: gemcitabine-resistant MIA PaCa-2-GR PDAC cell line and HPDE normal pancreatic cell line
Concentration: 30 nM - 10 μM
Incubation Time: 72 h
Result: Inhibited cell proliferation with an IC50 of 3.6 μM in MIA PaCa-2-GR cells and 4.5 μM in HPDE cells.

Cell Proliferation Assay[1]

Cell Line: MIA PaCa-2 PDAC cell line
Concentration: 30 nM - 10 μM; 5 mM NAC (pretreatment)
Incubation Time: 72 h
Result: Attenuated the proliferation inhibitory effect of QD 232 when cells were pretreated with 5 mM NAC, though protection was not complete.
In Vivo

QD 232 (20 mg/kg; five days on/two days off cycles; 31 days) achieves 65% tumor growth suppression in a MIA PaCa-2 pancreatic ductal adenocarcinoma xenograft model in 6-week-old NOD/SCID mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/SCID mice with Pancreatic ductal adenocarcinoma (6-week-old)[1]
Dosage: 20 mg/kg
Administration: 5 days on/two days off cycles; 31 days
Result: Suppressed tumor growth by 65% over the 31-day study period.
Molecular Weight

293.28

Formula

C16H11N3O3
CAS No.
SMILES

O=C1C=C(NC2=CC=CC(=C2)C(=O)C)C(=O)C=3C=NC=NC13
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Room temperature in continental US; may vary elsewhere.
Storage

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QD 232 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QD 2321527467-32-8QD232QD-232ApoptosisDNA/RNA SynthesisReactive Oxygen Species (ROS)Keap1-Nrf2Panc-1unfolded protein responsemtDNA transcriptionapoptosispancreatic ductal adenocarcinomaHPDE pancreatic cellsBxPC-3MIA PaCa-2-GRMIA PaCa-2NRF2-mediated oxidative stress responseInhibitorinhibitorinhibit

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