2. NF-κB
  3. NF-κB
  4. Quinoclamine

Quinoclamine 

Cat. No.: HY-121632 Purity: 99.01%
COA Handling Instructions

Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity.

For research use only. We do not sell to patients.

Quinoclamine Chemical Structure

Quinoclamine Chemical Structure

CAS No. : 2797-51-5

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Solution
10 mM * 1 mL in DMSO USD 127 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 127 In-stock
Solid
100 mg USD 115 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Quinoclamine Related Antibodies

Top Publications Citing Use of Products

View All NF-κB Isoform Specific Products:

View All Isoforms
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity[1][2].

IC50 & Target

NF-κB[2]
In Vitro

Quinoclamine causes differentiation of U-937 cells into macrophage-like cells[1].
Quinoclamine inhibits NF-κB activities in HepG2 cells, with an IC50 of 1.7 μM[2].
Quinoclamine (1-4 μM; 30 minutes ) suppresses endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation[2].
Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines[2].
Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis[2].
Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Quinoclamine Related Antibodies

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 1 μM, 2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM
Incubation Time: 24 hours
Result: Inhibited NF-κB activities in HepG2 cells.

Western Blot Analysis[2]

Cell Line: HepG2 cells
Concentration: 0 μM, 1 μM, 2 μM, 4 μM
Incubation Time: 30 minutes
Result: Inhibited IκB-α phosphorylation and p65 translocation in HepG2 cells.
Molecular Weight

207.61

Appearance

Solid

Formula

C10H6ClNO2
CAS No.
SMILES

O=C(C(Cl)=C(C1=O)N)C2=C1C=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1204.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8167 mL 24.0836 mL 48.1672 mL
5 mM 0.9633 mL 4.8167 mL 9.6334 mL
10 mM 0.4817 mL 2.4084 mL 4.8167 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (10.02 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Quinoclamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Quinoclamine2797-51-5NF-κBNuclear factor-κBNuclear factor-kappaBNF-ΚbnaphthoquinonederivativeInhibitorinhibitorinhibit

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