1. NF-κB
  2. NF-κB
  3. Quinoclamine

Quinoclamine 

Cat. No.: HY-121632 Purity: 99.01%
Handling Instructions

Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity.

For research use only. We do not sell to patients.

Quinoclamine Chemical Structure

Quinoclamine Chemical Structure

CAS No. : 2797-51-5

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10 mM * 1 mL in DMSO USD 127 In-stock
Estimated Time of Arrival: December 31
100 mg USD 115 In-stock
Estimated Time of Arrival: December 31
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Description

Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity[1][2].

IC50 & Target

NF-κB[2]

In Vitro

Quinoclamine causes differentiation of U-937 cells into macrophage-like cells[1].
Quinoclamine inhibits NF-κB activities in HepG2 cells, with an IC50 of 1.7 μM[2].
Quinoclamine (1-4 μM; 30 minutes ) suppresses endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation[2].
Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines[2].
Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis[2].
Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism[2].

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 1 μM, 2 μM, 4 μM, 8 μM, 16 μM, 32 μM, 64 μM
Incubation Time: 24 hours
Result: Inhibited NF-κB activities in HepG2 cells.

Western Blot Analysis[2]

Cell Line: HepG2 cells
Concentration: 0 μM, 1 μM, 2 μM, 4 μM
Incubation Time: 30 minutes
Result: Inhibited IκB-α phosphorylation and p65 translocation in HepG2 cells.
Molecular Weight

207.61

Formula

C₁₀H₆ClNO₂

CAS No.

2797-51-5

SMILES

O=C(C(Cl)=C(C1=O)N)C2=C1C=CC=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (1204.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8167 mL 24.0836 mL 48.1672 mL
5 mM 0.9633 mL 4.8167 mL 9.6334 mL
10 mM 0.4817 mL 2.4084 mL 4.8167 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (10.02 mM); Clear solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

QuinoclamineNF-κBNuclear factor-κBNuclear factor-kappaBNF-ΚbnaphthoquinonederivativeInhibitorinhibitorinhibit

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Quinoclamine
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