1. Immunology/Inflammation
    GPCR/G Protein
  2. COX
    Prostaglandin Receptor
  3. Rebamipide

Rebamipide (Synonyms: OPC12759; Proamipide)

Cat. No.: HY-B0360 Purity: 99.88%
Handling Instructions

Rebamipide (OPC12759) is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner.

For research use only. We do not sell to patients.

Rebamipide Chemical Structure

Rebamipide Chemical Structure

CAS No. : 90098-04-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 168 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Rebamipide (OPC12759) is a mucoprotective agent. Rebamipide induces COX-2 expression, increases PGE2 levels, and enhances gastric mucosal defense in a COX-2-dependent manner[1].

IC50 & Target

COX-2

 

PGE2

 

Clinical Trial
Molecular Weight

370.79

Formula

C₁₉H₁₅ClN₂O₄

CAS No.

90098-04-7

SMILES

OC(C(NC(C1=CC=C(Cl)C=C1)=O)CC(C2=CC=CC=C2N3)=CC3=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (134.85 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6969 mL 13.4847 mL 26.9694 mL
5 mM 0.5394 mL 2.6969 mL 5.3939 mL
10 mM 0.2697 mL 1.3485 mL 2.6969 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.74 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

RebamipideOPC12759 ProamipideOPC 12759OPC-12759COXProstaglandin ReceptorCyclooxygenaseCOX-2PGE2gastricmucosaldefensemucoprotectiveInhibitorinhibitorinhibit

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Product Name:
Rebamipide
Cat. No.:
HY-B0360
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