1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Salvinorin A

Salvinorin A (Synonyms: Divinorin A)

Cat. No.: HY-100845 Purity: >98.0%
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Salvinorin A is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.3 nm. Salvinorin A is a non-nitrogenous neoclerodane isolated from Salvia divinorum.

For research use only. We do not sell to patients.

Salvinorin A Chemical Structure

Salvinorin A Chemical Structure

CAS No. : 83729-01-5

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10 mM * 1 mL in DMSO USD 1094 In-stock
Estimated Time of Arrival: December 31
1 mg USD 390 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1150 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Salvinorin A is a potent, unique and short-acting high efficacy kappa-opioid receptor (KOPr) agonist with Ki value of 4.3 nm. Salvinorin A is a non-nitrogenous neoclerodane isolated from Salvia divinorum.

IC50 & Target

Ki:4.3 nm (kappa-opioid receptor)[1]

In Vitro

Salvinorin A (Divinorin A)(0.01-10 pM; pre-30 minues; 24 hours) does not affect the membrane function after 24-h exposure in macrophages[1].
Salvinorin A (Divinorin A) (0.01-10 pM; pre-30 minues; 18 hours) before LPS stimulation causes a significant and concentrationdependent manner reduction of LPS-stimulated nitrite levels, the IC50 (95% CL) of salvinorin A inhibitory effect was 6.5×10−13M[1].
Salvinorin A (Divinorin A) (0.01-10 pM; pre-30 minues; 18 hours) incubates 30 min before LPS stimulation, reduces in concentration-dependent manner the LPSinduced iNOS, but not COX-2, hyperexpression, reaching a statistical significance at the 10 pM concentration[1].

In Vivo

Salvinorin A (intraperitoneal injection; 0.5-2 mg/kg; pre-treatment 30 minutes) at the 0.5 mg/kg dose is the most effective one, at the dose of 0.5 mg/kg, significantly inhibits oedema during the first 6 h; at the dose of 1 mg/kg, salvinorin A significantly reduces the oedema only 4 h after carrageenan injection; at the highest doses tested (2 mg/kg), salvinorin A fails to evoke significant changes on the carrageenan-induced paw oedema[1].

Molecular Weight

432.46

Formula

C₂₃H₂₈O₈

CAS No.

83729-01-5

SMILES

C[[email protected]@]([[email protected]@]1([H])CC2)(C[[email protected]@H](C3=COC=C3)OC1=O)[[email protected]](C([[email protected]@H](OC(C)=O)C4)=O)([H])[[email protected]@]2([[email protected]@H]4C(OC)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

Salvinorin ADivinorin AOpioid ReceptorhallucinogenInhibitorinhibitorinhibit

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Salvinorin A
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