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PLD2 - phospholipase D2 Gene

Also Known as PLD1C

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5338

About PLD2

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,807,152-4,823,430 (from NCBI)

This gene has 15 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 17.0), skin (RPKM 14.6) and 23 other tissues.

Summary

The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PLD2 Products (2)

mRNA	Protein	Name
NM_001243108.2	NP_001230037.1	phospholipase D2 isoform PLD2B
NM_002663.5	NP_002654.3	phospholipase D2 isoform PLD2A

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16407827	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLD2 Protein Structure

PLDc

PLDc_2

0
200
400
600
800
933 a.a.

Protein Preferred Names	Protein Names
phospholipase D2	choline phosphatase 2

PLD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PLD2	O14939	CFL1	Homo sapiens	P23528	Anti Bait CoIP	17853892
Intra	PLD2	O14939	CFL1	Homo sapiens	P23528	Pull Down	17853892
Intra	PLD2	O14939	GRB2	Homo sapiens	P62993	Pull Down	16407827
Intra	PLD2	O14939	RAC2	Homo sapiens	P15153	Anti Tag CoIP	22106281
Intra	PLD2	O14939	RAC2	Homo sapiens	P15153	Solid Phase Assay	22106281
Intra	PLD2	O14939	RAC2	Homo sapiens	P15153	GDP/GTP Exchange	22106281
Intra	PLD2	O14939	RAC2	Homo sapiens	P15153	Pull Down	22106281
Intra	PLD2	O14939	APP	Homo sapiens	P05067	Y2H Pooling	32814053
Intra	PLD2	O14939	APP	Homo sapiens	P05067	Validated Y2H	32814053
Intra	PLD2	O14939	APP	Homo sapiens	P05067	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

PLD2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83818	PLD2 Antibody (YA3515)	IHC-P, ICC/IF, FC, ELISA	Human
HY-P83818A	PLD2 Antibody (YA3515)(PBS only)	IHC-P, ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Parkinson Disease 6, Autosomal Recessive Early-Onset	Autosomal Recessive Early-Onset Parkinson Disease 6 Parkinson Disease 6 PARK6 Parkinson Disease 6, Early Onset Parkinson'S Disease 6 Parkinson Disease 6, Early-Onset Autosomal Recessive Early-Onset Parkinson'S Disease 6 Early-Onset Parkinson Disease 6 Autosomal Recessive Early-Onset Parkinson Disease Type 6 Parkinson Disease 6 Early-Onset Parkinson Disease 6 Late-Onset Susceptibility To Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1 Parkinsonism Young Adult Onset Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1 Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Pheochromocytoma	Pheochromocytoma, Susceptibility To Phaeochromocytoma Adrenal Gland Chromaffin Paraganglioma Adrenal Gland Chromaffinoma Adrenal Gland Paraganglioma Adrenal Gland Pheochromocytoma Chromaffin Paraganglioma Of The Adrenal Gland Intraadrenal Paraganglioma PCC Chromaffin Cell Tumor Medullary Chromaffinoma Medullary Paraganglioma Pheochromoblastoma Pheochromocytomas Chromaffin Cell Neoplasm Pheochromocytoma, Malignant
Hermansky-Pudlak Syndrome 1	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells HPS1 Delta Storage Pool Disease Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Hermansky-Pudlak Syndrome, Type 1 Platelet Storage Pool Deficiency
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12807	FIPI	Inhibitor	98.00%	Unkown
HY-101293	VU0359595	Inhibitor	98.06%	Unkown
HY-121983	CAY10594		98.64%	Unkown
HY-150412	VU0364739	Inhibitor	99.16%	Unkown
HY-119093	Halopemide		99.65%	Unkown
HY-116165	ML-298	Inhibitor	96.94%	Unkown
HY-155342	A3373	Inhibitor	99.57%	Unkown
HY-114095	BML-280	Inhibitor	99.64%	Unkown
HY-108616	VU 0364739 hydrochloride	Inhibitor	/	Unkown
HY-RS19152	Pld2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-12807A	FIPI hydrochloride	Inhibitor	/	Unkown
HY-108612A	VU0155069 hydrochloride	Inhibitor	/	Unkown
HY-124305	ML395		/	Unkown
HY-155343	A4333	Inhibitor	/	Unkown
HY-RS10671	PLD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25641	Pld2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLD2	RGD	RGD:3350
Bos taurus	PLD2	VGNC	VGNC:32996
Mus musculus	PLD2	MGD	MGI:892877
Felis catus	PLD2	VGNC	VGNC:68902
Canis familiaris	PLD2	VGNC	VGNC:44661
Macaca mulatta	PLD2	VGNC	VGNC:76172
Others	PLD2	NCBI