1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. VU 0364739 hydrochloride

VU 0364739 hydrochloride is a highly selective phospholipase D2 (PLD2) inhibitor with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively. VU 0364739 hydrochloride induces apoptosis and it can be used for cancer research.

For research use only. We do not sell to patients.

VU 0364739 hydrochloride Chemical Structure

VU 0364739 hydrochloride Chemical Structure

CAS No. : 1244640-48-9

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Based on 1 publication(s) in Google Scholar

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Description

VU 0364739 hydrochloride is a highly selective phospholipase D2 (PLD2) inhibitor with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively. VU 0364739 hydrochloride induces apoptosis and it can be used for cancer research[1].

IC50 & Target

PLD2

20 nM (IC50)

PLD1

1500 nM (IC50)

In Vitro

VU 0364739 (1, 5 and 10 μM; 24, 48, 72 and 96 hours) time- and dose-dependently decreases cell proliferation of MDA-MB-231 cells under serum-free conditions[1].
VU 0364739 (1, 10 and 100 μM; 48 hours) increases Caspase 3 and 7 activities at a dose of 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231 cell line
Concentration: 10 μM
Incubation Time: 24 hours
Result: Inhibited cell proliferation of MDA-MB-231 cells.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cell line
Concentration: 1, 10 and 100 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis at a dose of 10 μM under serum-free condition or 10% FBS containg condition.
In Vivo

1.19 Pharmacokinetic Properties of VU 0364739 in Rats[1].

Rats
IV 1 mg/kg
Rats
PO 10 mg/kg
CL (mL/min/kg) 61.5
t1/2 (h) 1.52
Vdss (L/kg) 8.1
plasma (ng/mL) 39.9
brain (ng/mL) 29

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

482.98

Formula

C26H28ClFN4O2

CAS No.
SMILES

O=C(C1=CC=C2C=CC=CC2=C1)NCCN(CC3)CCC3(N(C4=CC=CC(F)=C4)CN5)C5=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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VU 0364739 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
VU 0364739 hydrochloride
Cat. No.:
HY-108616
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