VU 0364739 hydrochloride
VU 0364739 hydrochloride is a highly selective phospholipase D2 (PLD2) inhibitor with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively. VU 0364739 hydrochloride induces apoptosis and it can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 1244640-48-9
- Formula: C26H28ClFN4O2
- Molecular Weight:482.98
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Phospholipase Isoforms
More
Biological Activity
|
PLD2 20 nM (IC50) |
PLD1 1500 nM (IC50) |
VU 0364739 (1, 5 and 10 μM; 24, 48, 72 and 96 hours) time- and dose-dependently decreases cell proliferation of MDA-MB-231 cells under serum-free conditions[1]. VU 0364739 (1, 10 and 100 μM; 48 hours) increases Caspase 3 and 7 activities at a dose of 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-231 cell line
-
Concentration:10 μM
-
Incubation Time:24 hours
-
Result:Inhibited cell proliferation of MDA-MB-231 cells.
-
Cell Line:MDA-MB-231 cell line
-
Concentration:1, 10 and 100 μM
-
Incubation Time:48 hours
-
Result:Induced cell apoptosis at a dose of 10 μM under serum-free condition or 10% FBS containg condition.
| Rats IV 1 mg/kg |
Rats PO 10 mg/kg |
|
| CL (mL/min/kg) | 61.5 | |
| t1/2 (h) | 1.52 | |
| Vdss (L/kg) | 8.1 | |
| plasma (ng/mL) | 39.9 | |
| brain (ng/mL) | 29 | |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1244640-48-9
-
Molecular Weight 482.98
-
Formula C26H28ClFN4O2
-
SMILES
O=C(C1=CC=C2C=CC=CC2=C1)NCCN(CC3)CCC3(N(C4=CC=CC(F)=C4)CN5)C5=O.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VU 0364739 hydrochloride Related Classifications
HY-108616 Related Classifications
Powered by Bioz