1. Metabolic Enzyme/Protease
    Apoptosis
  2. Phospholipase
    Apoptosis
  3. m-3M3FBS

m-3M3FBS 

Cat. No.: HY-19619
Handling Instructions

m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis.

For research use only. We do not sell to patients.

m-3M3FBS Chemical Structure

m-3M3FBS Chemical Structure

CAS No. : 200933-14-8

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Description

m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis[1][2][3].

In Vitro

m-3M3FBS (5-50 μM) stimulates the formation of inositol phosphates in U937 cells[1].
m-3M3FBS (50 μM; 24 hours) inhibits the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes[3].
m-3M3FBS (50 μM; 24 hours) induces U937 cell apoptosis[3].

Cell Viability Assay[3]

Cell Line: U937 and THP-1 cells
Concentration: 50 μM
Incubation Time: 24 hours
Result: Inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes.

Cell Viability Assay[3]

Cell Line: U937 cells
Concentration: 50 μM
Incubation Time: 24 hours
Result: The apoptotic rate of m-3M3FBS-treated cells was 53.9%.
Molecular Weight

343.36

Formula

C₁₆H₁₆F₃NO₂S

CAS No.

200933-14-8

SMILES

O=S(C1=C(C)C=C(C)C=C1C)(NC2=CC=CC(C(F)(F)F)=C2)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

m-3M3FBSPhospholipaseApoptosissuperoxideneutrophilsinositolphosphateleukemiccellsU937calciumTHP-1Inhibitorinhibitorinhibit

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m-3M3FBS
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HY-19619
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