200933-14-8
200933-14-8
Chemical Structure
m-3M3FBS
- CAS No.: 200933-14-8
- Formula:C16H16F3NO2S
- Molecular Weight:343.36
IUPAC Name: 2,4,6-trimethyl-N-(3-(trifluoromethyl)phenyl)benzenesulfonamide
InChIKey: ZIIUUSVHCHPIQD-UHFFFAOYSA-N
SMILES: O=S(C1=C(C)C=C(C)C=C1C)(NC2=CC=CC(C(F)(F)F)=C2)=O
Biological Activity: m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis[1][2][3].
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m-3M3FBS | 99.99% | m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis. | ||||||||||||||||||||
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m-3M3FBS (Standard) | ≥98% | m-3M3FBS (Standard) is the analytical standard of m-3M3FBS. This product is intended for research and analytical applications. m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.83
HY-108608o-3M3FBS -
Similarity Score 0.66
HY-19995GSK137647A -
Similarity Score 0.65
HY-402361TERT activator-1 -
Similarity Score 0.64
HY-138956MAY0132 -
Similarity Score 0.64
HY-117656ESI-05 -
Similarity Score 0.64
HY-120697MSAB -
Similarity Score 0.62
HY-156966ATG12-ATG3 inhibitor 1 -
Similarity Score 0.60
HY-180864CA12 modulator-1 -
Similarity Score 0.60
HY-B1221RFlufenamic acid (Standard) -
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References
- [1]. Bae YS, et al. Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol. 2003;63(5):1043-1050. [Content Brief]
- [2]. Krjukova J, et al. Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br J Pharmacol. 2004;143(1):3-7. [Content Brief]
- [3]. Lee YN, et al. The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 2005;222(2):227-235. [Content Brief]
