ML-298

Cat. No.: HY-116165 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC₅₀ of 355 nM. ML298 decreases invasive migration in U87-MG glioblastoma cells.

For research use only. We do not sell to patients.

ML-298 Chemical Structure

CAS No. : 1426916-02-0

Size	Price	Stock	Quantity
5 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Phospholipase A PLD

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References
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Description

ML298 is a potent and selective inhibitor of Phospholipase D2 (PLD2) with an IC₅₀ of 355 nM. ML298 decreases invasive migration in U87-MG glioblastoma cells^[1].

Molecular Weight

432.44

Formula

C₂₂H₂₃F₃N₄O₂

CAS No.

1426916-02-0

Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C(C=C1F)C(NCCN2CCC3(CC2)C(NCN3C4=CC(F)=CC=C4)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (289.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3125 mL	11.5623 mL	23.1246 mL
5 mM	0.4625 mL	2.3125 mL	4.6249 mL
10 mM	0.2312 mL	1.1562 mL	2.3125 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. O'Reilly MC, et al. Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells. J Med Chem. 2013 Mar 28;56(6):2695-9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3125 mL	11.5623 mL	23.1246 mL	57.8115 mL
	5 mM	0.4625 mL	2.3125 mL	4.6249 mL	11.5623 mL
	10 mM	0.2312 mL	1.1562 mL	2.3125 mL	5.7811 mL
	15 mM	0.1542 mL	0.7708 mL	1.5416 mL	3.8541 mL
	20 mM	0.1156 mL	0.5781 mL	1.1562 mL	2.8906 mL
	25 mM	0.0925 mL	0.4625 mL	0.9250 mL	2.3125 mL
	30 mM	0.0771 mL	0.3854 mL	0.7708 mL	1.9270 mL
	40 mM	0.0578 mL	0.2891 mL	0.5781 mL	1.4453 mL
	50 mM	0.0462 mL	0.2312 mL	0.4625 mL	1.1562 mL
	60 mM	0.0385 mL	0.1927 mL	0.3854 mL	0.9635 mL
	80 mM	0.0289 mL	0.1445 mL	0.2891 mL	0.7226 mL
	100 mM	0.0231 mL	0.1156 mL	0.2312 mL	0.5781 mL

ML-298 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ML-2981426916-02-0ML298ML 298PhospholipaseInhibitorinhibitorinhibit

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