2. Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
  3. Phospholipase Dopamine Receptor
  4. Halopemide

Halopemide is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent.

For research use only. We do not sell to patients.

Halopemide Chemical Structure

Halopemide Chemical Structure

CAS No. : 59831-65-1

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 176 In-stock
Solution
10 mM * 1 mL in DMSO USD 176 In-stock
Solid
1 mg USD 64 In-stock
5 mg USD 160 In-stock
10 mg USD 260 In-stock
25 mg USD 520 In-stock
50 mg USD 830 In-stock
100 mg USD 1330 In-stock
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Based on 1 publication(s) in Google Scholar

Halopemide Related Antibodies

Top Publications Citing Use of Products

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Phospholipase A PLD

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Halopemide is a potent phospholipase D (PLD) inhibitor, with IC50s of 220 and 310 nM for human PLD1 and PLD2, respectively. Halopemid is a dopamine receptors antagonist, and acts a psychotropic agent[1][2].

IC50 & Target[1][2]

D1 Receptor

 

D2 Receptor

 

PLD1

220 nM (IC50)

PLD2

310 nM (IC50)

In Vitro

Halopemide (1-2 μM; 21 day) affects calcification in transdifferentiated MOVAS cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Halopemide Related Antibodies
In Vivo

Halopemide (10 mg/kg; p.o.) induces dyskinesias in the majority of monkeys tested[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

416.88

Formula

C21H22ClFN4O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(C=C1)F)NCCN2CCC(CC2)N3C4=CC=C(C=C4NC3=O)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (99.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3988 mL 11.9939 mL 23.9877 mL
5 mM 0.4798 mL 2.3988 mL 4.7975 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.65%

COA (251 KB) LCMS (98 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3988 mL 11.9939 mL 23.9877 mL 59.9693 mL
5 mM 0.4798 mL 2.3988 mL 4.7975 mL 11.9939 mL
10 mM 0.2399 mL 1.1994 mL 2.3988 mL 5.9969 mL
15 mM 0.1599 mL 0.7996 mL 1.5992 mL 3.9980 mL
20 mM 0.1199 mL 0.5997 mL 1.1994 mL 2.9985 mL
25 mM 0.0960 mL 0.4798 mL 0.9595 mL 2.3988 mL
30 mM 0.0800 mL 0.3998 mL 0.7996 mL 1.9990 mL
40 mM 0.0600 mL 0.2998 mL 0.5997 mL 1.4992 mL
50 mM 0.0480 mL 0.2399 mL 0.4798 mL 1.1994 mL
60 mM 0.0400 mL 0.1999 mL 0.3998 mL 0.9995 mL
80 mM 0.0300 mL 0.1499 mL 0.2998 mL 0.7496 mL
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Halopemide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Halopemide59831-65-1PhospholipaseDopamine ReceptorpsychotropiccalcificationdyskinesiascancerMOVAScellsInhibitorinhibitorinhibit

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