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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
44 Results for "
complement system
" in MedChemExpress (MCE) Product Catalog:
Products (44)
44 Results for "complement system" in MCE Product Catalog:
Cat. No.: HY-P1398
CAS No.: 301544-78-5
Target:
Research Areas:
Cat. No.: HY-W130878
CAS No.: 1806-26-4
Research Areas:
4-Octylphenol is a hormone disruptor that has gender-specific effects on male reproductive cells, significantly reducing the mitotic index and the number of spermatogonia. 4-Octylphenol can cause inflammatory damage to fish gills by activating the complement system through the C3a/C3aR axis and the C5a/C5aR1 axis, this leads to complement activation and causes immune suppression due to the imbalance between Th1/Th2 cells and regulatory T cells (Treg)/Th17 cells, as well as inflammatory damage via the Toll-like receptor 7 (Toll-like Receptor (TLR))/IκBα/NF-κB pathway .
Cat. No.: HY-163378
CAS No.: 2365325-67-1
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C5aR1 antagonist 1 (Compound 7e) is an orally active C5a receptor 1 (C5aR1) antagonist. C5aR1 antagonist 1 is active in DISCO and migration assays, with IC50 values of 38 nM and 17 nM, respectively. C5aR1 antagonist 1 can be used for the research of acute and chronic inflammatory diseases .
Cat. No.: HY-200854
CAS No.: 2447007-60-3
Synonyms: LNP023 hydrochloride hydrate
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Research Areas:
Iptacopan (LNP023) hydrochloride hydrate is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride hydrate exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride hydrate can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) .
Cat. No.: HY-W049802
CAS No.: 918531-01-8
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Cat. No.: HY-P5528
Cat. No.: HY-P1398A
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Cat. No.: HY-174913
CAS No.: 1644670-23-4
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Factor B-IN-5 is an orally active complement factor B (CFB) inhibitor. Factor B-IN-5 alleviates kidney damage in diabetes nephropathy by inhibiting the over activation of complement system and improving mitochondrial function. Factor B-IN-5 can improve renal tubulointerstitial inflammation and fibrosis. Factor B-IN-5 can be used for research on diabetic nephropathy .
Cat. No.: HY-147607
CAS No.: 2797066-85-2
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Factor B-IN-5 (Example 5 target compound) is a potent complement factor B inhibitor, with an IC50 of 1.2 μM. Factor B-IN-5 can be used for the research of diseases related to inflammation and immunity .
Cat. No.: HY-147604
CAS No.: 2760669-72-3
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Factor B-IN-2 (Example 1 target compound) is a potent complement factor B inhibitor, with an IC50 of 1.5 μM. Factor B-IN-2 can be used for the research of diseases related to inflammation and immunity .
Cat. No.: HY-147605
CAS No.: 2760669-74-5
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Factor B-IN-3 (Example 3 target compound) is a potent complement factor B inhibitor. Factor B-IN-3 can be used for the research of diseases related to inflammation and immunity .
Cat. No.: HY-147606
CAS No.: 2760669-84-7
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Factor B-IN-4 (Example 13 target compound) is a potent complement factor B inhibitor, with an IC50 of 1 μM. Factor B-IN-4 can be used for the research of diseases related to inflammation and immunity .
Cat. No.: HY-N7955
CAS No.: 372096-70-3
Category:
Actaea heracleifolia (Kom.) J. Compton Tetracyclic Triterpenoids Terpenoids Ranunculaceae Plants
Target:
Cat. No.: HY-N19128
CAS No.: 1476801-10-1
Target:
Cat. No.: HY-P72723
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD46; CD46 Molecule, complement Regulatory Protein; Prev. MIC10; Trophoblast Leukocyte Common Antigen; Prev. MCP; MGC26544; TLX; complement system Membrane Cofactor Protein CD46; Membrane Cofactor Protein; complement Membrane Cofactor Protein; TRA2.10; Tr
Cat. No.: HY-P700681
Purity: ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CD46; CD46 Molecule, complement Regulatory Protein; Prev. MIC10; Trophoblast Leukocyte Common Antigen; Prev. MCP; MGC26544; TLX; complement system Membrane Cofactor Protein CD46; Membrane Cofactor Protein; complement Membrane Cofactor Protein; TRA2.10; Tr
Species:
Source:
Cat. No.: HY-P72020
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD46; CD46 Molecule, complement Regulatory Protein; Prev. MIC10; Trophoblast Leukocyte Common Antigen; Prev. MCP; MGC26544; TLX; complement system Membrane Cofactor Protein CD46; Membrane Cofactor Protein; complement Membrane Cofactor Protein; TRA2.10; Tr
Cat. No.: HY-P700680
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD46; CD46 Molecule, complement Regulatory Protein; Prev. MIC10; Trophoblast Leukocyte Common Antigen; Prev. MCP; MGC26544; TLX; complement system Membrane Cofactor Protein CD46; Membrane Cofactor Protein; complement Membrane Cofactor Protein; TRA2.10; Tr
Cat. No.: HY-P85894
Synonyms: C3 binding protein; C3b/C4b receptor; C3BR; C4BR; CD 35; CD35; CD35 antigen; complement component; 3b/4b; receptor 1; Knops blood group; complement component; 3b/4b; receptor 1 including Knops blood group system; complement component receptor 1; complement receptor 1; complement receptor type 1; CR 1; CR1; CR1_HUMAN; KN; Knops blood group antigen
Cat. No.: HY-N17326
CAS No.: 242794-72-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
