2365325-67-1
2365325-67-1
Chemical Structure
C5aR1 antagonist 1
- CAS No.: 2365325-67-1
- Formula:C28H27F4N3O
- Molecular Weight:497.53
InChIKey: IUTHEOCJFAFDRT-UHFFFAOYSA-N
SMILES: O=C1N(CC2=C(C(F)(F)F)C=CC=C2)C3=C(CN1C4CCN(CC4)C5=C(C)C=CC=C5F)C=CC=C3
Biological Activity: C5aR1 antagonist 1 (Compound 7e) is an orally active C5a receptor 1 (C5aR1) antagonist. C5aR1 antagonist 1 is active in DISCO and migration assays, with IC50 values of 38 nM and 17 nM, respectively. C5aR1 antagonist 1 can be used for the research of acute and chronic inflammatory diseases[1].
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C5aR1 antagonist 1 | C5aR1 antagonist 1 (Compound 7e) is an orally active C5a receptor 1 (C5aR1) antagonist. C5aR1 antagonist 1 is active in DISCO and migration assays, with IC50 values of 38 nM and 17 nM, respectively. C5aR1 antagonist 1 can be used for the research of acute and chronic inflammatory diseases. | |||||||||||||||||||||
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