CD46 Protein, Cynomolgus (HEK293, His)

CD46 protein acts as a crucial cofactor for complement factor I, a serine protease protecting autologous cells by cleaving deposited C3b and C4b. In addition to complement regulation, CD46 is involved in sperm-oocyte fusion during fertilization. Acting as a costimulatory factor for T-cells, it promotes the differentiation of CD4+ cells into T-regulatory 1 cells, crucial for immune modulation by secreting interleukin-10, suppressing immune responses, and preventing autoimmunity. CD46 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived CD46 protein, expressed by HEK293, with C-His labeled tag. The total length of CD46 Protein, Cynomolgus (HEK293, His) is 295 a.a., with molecular weight of 50-70 kDa.

CD46 protein serves as a crucial cofactor for complement factor I, a serine protease responsible for safeguarding autologous cells against complement-mediated damage by cleaving deposited C3b and C4b on host tissue. Beyond its role in complement regulation, CD46 is implicated in the fusion process between spermatozoa and oocytes during fertilization. Additionally, CD46 acts as a costimulatory factor for T-cells, facilitating the differentiation of CD4+ cells into T-regulatory 1 cells. These specialized T-regulatory 1 cells contribute to immune modulation by secreting interleukin-10, thereby playing a pivotal role in suppressing immune responses and preventing autoimmunity.

Cynomolgus

HEK293

C-His

A0A2K5WCS2 (C35-D329)

102146832

50-70 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.