1 Result for "

1406-66-2

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "1406-66-2" in MCE Product Catalog:

Tocopherols
Tocopherols
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Cat. No.: HY-126400
CAS No.: 1406-66-2
Purity:  98.6%
Category:  

Nitrariaceae Natural Products Peganum harmala L. Plants

Target:  

Endogenous Metabolite Ferroptosis Reactive Oxygen Species (ROS) c-Myc

Tocopherols are orally effective antioxidants and ferroptosis inhibitors. Tocopherols scavenge ROS/RNS, alleviate DNA damage, downregulate cyclin D1/c-Myc/TFF/pS2/PGR in an ER-dependent manner, and inhibit ferroptosis mediated by lipid peroxidation. Tocopherols block the occurrence of ferroptosis in Gpx4-knockout Pfa1 cells, with an EC50 value of 1.0-2.3 μM. Tocopherols inhibit tumor growth. Tocopherols can be used in studies related to estrogen-mediated ER + breast cancer, oxidative stress-induced carcinogenesis, and ferroptosis regulation .
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