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Results for "

3C-like

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) HCV (1) HIV (1) Influenza Virus (2) Isotope-Labeled Compounds (1) Reference Standards (2) SARS-CoV (13) Virus Protease (4)
By Research Areas:	Infection (16) Inflammation/Immunology (6)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138687

Nirmatrelvir Maximum Cited Publications 103 Publications Verification PF-07321332	SARS-CoV	Infection Inflammation/Immunology
Nirmatrelvir (PF-07321332) is a potent and orally active SARS-CoV 3C-like protease (3CL ^PRO) inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .

HY-172437

Secutrelvir S-892216	Virus Protease SARS-CoV	Infection
Secutrelvir is an oral SARS-CoV-2 3C-like protease (3CLpro) inhibitor and antiviral agent, with IC₅₀ values of 0.655 nM and 0.697 nM against SARS-CoV-2 3CLpro, respectively. Secutrelvir forms a reversible covalent bond with the catalytic cysteine C145 of SARS-CoV-2 3CLpro, thereby inhibiting viral replication. Secutrelvir exhibits activity against multiple SARS-CoV-2 variants and can be used in research related to coronavirus disease 2019 (COVID-19) ^[3].

HY-137048

PF-00835231 4 Publications Verification	SARS-CoV HIV HCV	Infection
PF-00835231 is a CoV-2 *cysteine 3C-like* protease (3CL ^pro) inhibitor, with IC₅₀**s of 0.27 nM and 4 nM for SARS CoV-2 and SARS CoV-1 3CL ^pro, respectively. PF-00835231 is developed for the research of anti-SARS-CoV-2/COVID-19. PF-00835231 can inhibit cell infections and also suppress infections in animal models ^[3].

HY-156651

Zevotrelvir EDP-235	SARS-CoV Virus Protease	Infection
Zevotrelvir (EDP-235) is a coronavirus inhibitor that can inhibit 229E hCoV and the SARS-CoV-2 3C-like (3CL) protease (IC₅₀ <0.1 mM). Zevotrelvir can be used in research on coronavirus infections .

HY-100943

Cinanserin hydrochloride 1 Publications Verification SQ 10643	5-HT Receptor Influenza Virus	Infection Inflammation/Immunology
Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT₂ receptor antagonist with a K_i of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT₂ than for the 5-HT₁ receptor (K_i of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro ^[3].

HY-P3794

Glu-Ala-Leu-Phe-Gln-pNA	Virus Protease	Infection
Glu-Ala-Leu-Phe-Gln-pNA is a Chiba virus 3C-like protease (CVP) substrate .

HY-138687R

Nirmatrelvir (Standard) PF-07321332 (Standard)	Reference Standards SARS-CoV	Infection Inflammation/Immunology
Nirmatrelvir (Standard) is the analytical standard of Nirmatrelvir. This product is intended for research and analytical applications. Nirmatrelvir (PF-07321332) is a potent and orally active SARS-CoV 3C-like protease (3CL ^PRO) inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .

HY-177910

Anticoronavirus agent-1	SARS-CoV	Infection
Anticoronavirus agent-1 (Compound IV-2) is a 1,4-naphthone compound and is a 3CL hydrolase inhibitor (3C-like proteinase) of the 19-nCoV novel coronavirus. Anticoronavirus agent-1 has low cytotoxity on HSF cells. Anticoronavirus agent-1 can be used for the study of the novel coronavirus .

HY-145435

SARS-CoV-2-IN-12	SARS-CoV	Infection
SARS-CoV-2-IN-12 (Compound 27) is a potent SARS-CoV-2-related 3C-like protease inhibitor (K_i=32.1 pM) for preventing SARS-CoV-2 viral replication and that could be useful in the research of COVID-19 .

HY-143470

SARS-CoV-2-IN-18	SARS-CoV	Infection
SARS-CoV-2-IN-18 (Compound 26) is a potent *SARS-CoV-2 3C-like* protease inhibitor with an IC₅₀** of 45 nM .

HY-151535

SARS-CoV-2 3CLpro-IN-5	SARS-CoV	Infection Inflammation/Immunology
SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor of 3C-like protease (3CL ^pro). SARS-CoV-2 3CLpro-IN-5 has inhibitory activity for 3CL ^pro with an IC₅₀ value of 3.8 nM. SARS-CoV-2 3CLpro-IN-5 has 9.0% oral bioavailability (BA). SARS-CoV-2 3CLpro-IN-5 can be used for the research of coronavirus disease 2019 (COVID-19) .

HY-138687S1

Nirmatrelvir-d6 PF-07321332-d₆	Isotope-Labeled Compounds SARS-CoV	Infection Inflammation/Immunology
Nirmatrelvir-d₆ (PF-07321332-d₆) is deuterium labeled Nirmatrelvir. Nirmatrelvir (PF-07321332) is a potent and orally active *SARS-CoV 3C-like* protease (3CL ^PRO)** inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .

HY-145277

SARS-CoV-2-IN-11	SARS-CoV	Infection
SARS-CoV-2-IN-11 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC₅₀ and EC₅₀ of 0.17 and 1.45 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals .

HY-145276

SARS-CoV-2-IN-10	SARS-CoV	Infection
SARS-CoV-2-IN-10 is a potent and nontoxic inhibitor of SARS-CoV-2 3CL protease (3CLpro) with an IC₅₀ and EC₅₀ of 0.13 and 1.03 nM, respectively. SARS-CoV-2 3C-like protease (3CLpro), an enzyme essential for viral replication, is an attractive target for intervention. SARS-CoV-2-IN-11 may lead to the emergence of effective SARS-CoV-2-specific antivirals .

HY-100943R

Cinanserin hydrochloride (Standard) SQ 10643 (Standard)	5-HT Receptor Reference Standards Influenza Virus	Infection Inflammation/Immunology
Cinanserin (hydrochloride) (Standard) is the analytical standard of Cinanserin (hydrochloride) (HY-100943). This product is intended for research and analytical applications. Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro ^[3].

HY-183752

CG-0988	SARS-CoV Virus Protease	Infection
CG-0988 is a selective SARS-CoV-2 3C-like protease (3CL ^pro) inhibitor with an IC₅₀ of 8.5 nM. CG-0988 functionally inhibits SARS-CoV-2 3CL ^pro, blocks SARS-CoV-2 replication, and exerts antiviral activity against SARS-CoV-2 variants. CG-0988 can be used in research related to coronavirus disease 2019 (COVID-19) .

Glu-Ala-Leu-Phe-Gln-pNA	Virus Protease	Infection
Glu-Ala-Leu-Phe-Gln-pNA is a Chiba virus 3C-like protease (CVP) substrate .

Species:	Virus (7)
Tag:	His (5) Tag Free (2) Avi (2)
Source:	Sf9 insect cells (2) E. coli (5)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P7429

	*SARS-CoV-2 3C-like* Proteinase (His)** M Proteinase; 3CL Proteinase; 2019-nCoV 3C-like Proteinase	Virus	E. coli
	SARS-CoV-2 3C-like Proteinase (His), His, expressed in E.coli, mediates viral polyprotein maturation and multiple cleavages of host proteins to modulate viral translation and transcription with a His tag at the N-terminus.

HY-P7429A

	*SARS-CoV-2 3C-like* Proteinase (N-His)** M Proteinase; 3CL Proteinase; 2019-nCoV 3C-like Proteinase	Virus	E. coli
	SARS-CoV-2 3C-like Proteinase (His), His, expressed in E.coli, mediates viral polyprotein maturation and multiple cleavages of host proteins to modulate viral translation and transcription with a His tag at the N-terminus.

HY-P78275

	*SARS-CoV-2 3CLpro/3C-like* protease Protein** 3C-like protease; 3CL Protease; 3CL-Mpro; 3CL Pro; COVID-19; M Proteinase; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease is a viral cysteine protease that plays a crucial role in the co-translational proteolytic processing of coronavirus polyproteins. Since no homologous proteins with similar cleavage sites exist in the human body, SARS-CoV-2 3CLpro/3C-like protease is a high-quality target for the development of drugs related to COVID-19. SARS-CoV-2 3CLpro/3C-like protease protein is a recombinant, untagged SARS-CoV-2 3CLpro/3C-like protease protein expressed by E.coli.

HY-P78275A

	*SARS-CoV-2 3CLpro/3C-like* protease Protein (Tag Free)** 3C-like protease; 3CL Protease; 3CL-Mpro; 3CL Pro; COVID-19; M Proteinase; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) is a viral cysteine protease that plays a crucial role in the co-translational proteolytic processing of coronavirus polyproteins. Since no homologous proteins with similar cleavage sites exist in the human body, SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) is a high-quality target for the development of drugs related to COVID-19. SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) is a recombinant, SARS-CoV-2 3CLpro/3C-like protease Protein (Tag Free) expressed by E.coli.

HY-P76590

	*SARS-CoV-2 3CLpro/3C-like* protease Protein (His-Avi)** 3CL Protease; 3CL Proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M Proteinase; Main Protease; Mpro	Virus	E. coli
	SARS-CoV-2 3CLpro/3C-like protease Protein (His-Avi) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by E. coli, with N-His, N-Avi labeled tag.

HY-P76589

	*SARS-CoV-2 3CLpro/3C-like* protease Protein (sf9, His)** 3CL Protease; 3CL Proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M Proteinase; Main Protease; Mpro	Virus	Sf9 insect cells
	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by Sf9 insect cells, with N-His labeled tag.

HY-P76591

	*SARS-CoV-2 3CLpro/3C-like* protease Protein (sf9, His-Avi)** 3CL Protease; 3CL Proteinase; 3C-like main protease; 3CL-Mpro; COVID-19; M Proteinase; Main Protease; Mpro	Virus	Sf9 insect cells
	SARS-CoV-2 3CLpro/3C-like protease Protein (sf9, His-Avi) is the recombinant Virus-derived SARS-CoV-2 3CLpro/3C-like protease protein, expressed by Sf9 insect cells, with N-His, N-Avi labeled tag.

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HY-138687S1

Nirmatrelvir-d6
Nirmatrelvir-d₆ (PF-07321332-d₆) is deuterium labeled Nirmatrelvir. Nirmatrelvir (PF-07321332) is a potent and orally active *SARS-CoV 3C-like* protease (3CL ^PRO)** inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research .

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