2913186-57-7
Chemical Structure
SARS-CoV-2 3CLpro-IN-5
- CAS No.: 2913186-57-7
- Formula:C22H26ClF2N5O4
- Molecular Weight:497.92
IUPAC Name: N-((S)-1-(2-((R)-2-chloro-2-fluoroacetyl)-2-(((S)-2-oxopyrrolidin-3-yl)methyl)hydrazinyl)-4-methyl-1-oxopentan-2-yl)-4-fluoro-1H-indole-2-carboxamide
InChIKey: AZMUHUYPUWGKJR-IWEFOYFVSA-N
SMILES: FC1=CC=CC2=C1C=C(C(N[C@H](C(NN(C([C@@](F)([H])Cl)=O)C[C@H]3C(NCC3)=O)=O)CC(C)C)=O)N2
Biological Activity: SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor of 3C-like protease (3CLpro). SARS-CoV-2 3CLpro-IN-5 has inhibitory activity for 3CLpro with an IC50 value of 3.8 nM. SARS-CoV-2 3CLpro-IN-5 has 9.0% oral bioavailability (BA). SARS-CoV-2 3CLpro-IN-5 can be used for the research of coronavirus disease 2019 (COVID-19)[1].
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SARS-CoV-2 3CLpro-IN-5 | SARS-CoV-2 3CLpro-IN-5 is a covalent inhibitor of 3C-like protease (3CLpro). SARS-CoV-2 3CLpro-IN-5 has inhibitory activity for 3CLpro with an IC50 value of 3.8 nM. SARS-CoV-2 3CLpro-IN-5 has 9.0% oral bioavailability (BA). SARS-CoV-2 3CLpro-IN-5 can be used for the research of coronavirus disease 2019 (COVID-19). | |||||||||||||||||||||
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Keywords
