54-84-2
54-84-2
Chemical Structure
Cinanserin hydrochloride
Synonym(s): SQ 10643
- CAS 番号: 54-84-2
- Formula:C20H25ClN2OS
- Molecular Weight:376.94
IUPAC Name: N-(2-((3-(dimethylamino)propyl)thio)phenyl)cinnamamide hydrochloride
InChIKey: LXGJPDKYMJJWRB-IERUDJENSA-N
SMILES: O=C(NC1=CC=CC=C1SCCCN(C)C)/C=C/C2=CC=CC=C2.[H]Cl
Biological Activity: Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro[1][2][3].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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Cinanserin hydrochloride | 99.48% | Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. | ||||||||||||||||||||
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Cinanserin hydrochloride (Standard) | ≥98% | Cinanserin (hydrochloride) (Standard) is the analytical standard of Cinanserin (hydrochloride) (HY-100943). This product is intended for research and analytical applications. Cinanserin hydrochloride (SQ 10643) is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. | ||||||||||||||||||||
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Iferanserin | 99.74% | Iferanserin (S-MPEC) is a selective 5-HT receptor (serotonin receptor) antagonist with an affinity for 5-HT2A receptor. Iferanserin has the potential for internal hemorrhoid disease treatment. | ||||||||||||||||||||
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Iferanserin hydrochloride | Iferanserin hydrochloride (S-MPEC hydrochloride) is a selective serotonin receptor antagonist with the potential to inhibit internal hemorrhoids. Iferanserin hydrochloride demonstrated efficacy and tolerability in ongoing Phase IIb clinical trials, with the ability to significantly reduce patient-reported symptoms of bleeding and pruritus. | |||||||||||||||||||||
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Cinanserin | Cinanserin (SQ 10643) is a potent and selective 5-HT2 antagonist with Ki values of 41, 3500 nM for 5-HT2, 5-HT1, respectively. Cinanserin also is a SARS-CoV 3CLpro inhibitor with an KD value of 49.4, 18.2 µM for SARS-CoV 3CLpro, HCoV-229E 3CLpro, respectively. Cinanserin reduces systemic burn edema levels. | |||||||||||||||||||||
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SQ 11,447 | SQ 11,447 is a methylurea analogue that demonstrates remarkable resistance to hydrolysis in both in vitro (rat, dog, and human liver homogenates) and in vivo (rat) experimental models. | |||||||||||||||||||||
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Pyramidatine | Pyramidatine (Haplamidine) is a P-glycoprotein inhibitor with an IC50 of 39.29 µM. As a sensitizer, Pyramidatine enhances Vincristine (HY-N0488A)-induced Apoptosis and G2/M phase arrest, while potentiating the activity of Vincristine against drug-resistant oral cancer. Pyramidatine can be used in research related to oral cancer and mammary adenocarcinoma. | |||||||||||||||||||||
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N-Phenethylcinnamamide | N-Phenethylcinnamamide is a natural alkaloid. | |||||||||||||||||||||
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Lansiumamide A | Lansiumamide A is a cinnamamide derivative found in the seeds of Clausena lansium. | |||||||||||||||||||||
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(E)-N-(3-Methoxyphenyl)cinnamamide | (E)-N-(3-Methoxyphenyl) cinnamamide (Compound 5h) is a weakly selective inhibitor of MMP-2 and MMP-9, with weak inhibitory activity against hMMP-2 and hMMP-9, showing IC50 values of 1674.81 nM and 1658.63 nM, respectively, and low selectivity for MMP-1. (E)-N-(3-Methoxyphenyl) cinnamamide is applicable for cancer research. | |||||||||||||||||||||
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(E)-N-(4-Methoxyphenyl)cinnamamide | (E)-N-(4-Methoxyphenyl)cinnamamide is a selective matrix metalloproteinase inhibitor with inhibitory activity against MMP-2 (IC50 = 5.37 nM), MMP-9 (IC50 = 6.21 nM), and low activity against MMP-1 (IC50 = 5301.68 nM). (E)-N-(4-Methoxyphenyl)cinnamamide can be used for the research of tumor. | |||||||||||||||||||||
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(E)-N-(2-Fluorophenyl)cinnamamide | (E)-N-(2-Fluorophenyl) cinnamamide (Compound 5m) is a MMP-2 and MMP-9 inhibitor, with selectivity over MMP-1. Its IC50 values against MMP-2, MMP-9 and MMP-1 are 9.09 nM, 8.02 nM and 4117.53 nM, respectively. (E)-N-(2-Fluorophenyl) cinnamamide can be used in the research of metastatic tumors. | |||||||||||||||||||||
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References
- [1]. Chen L, et al. Cinanserin is an inhibitor of the 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro. J Virol. 2005 Jun;79(11):7095-103. [Content Brief]
- [2]. Hernekamp JF, et al. Cinanserin reduces plasma extravasation after burn plasma transfer in rats. Burns. 2013 Sep;39(6):1226-33. [Content Brief]
- [3]. Leysen JE, et al. Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. Life Sci. 1981 Mar 2;28(9):1015-22. [Content Brief]
