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5-Hydroxytryptophan

" in MedChemExpress (MCE) Product Catalog:

25

Inhibitors & Agonists

1

Biochemical Assay Reagents

12

Peptides

7

Natural
Products

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N0122
    5-Hydroxytryptophan
    2 Publications Verification

    5-HTP; DL-5-Hydroxytryptophan

    		 Endogenous Metabolite 5-HT Receptor Neurological Disease Metabolic Disease
    5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .
    5-Hydroxytryptophan
  • HY-17365
    Octreotide acetate
    15+ Cited Publications

    SMS 201-995 acetate

    		 Somatostatin Receptor Cardiovascular Disease Inflammation/Immunology Endocrinology Cancer
    Octreotide acetate, a long-acting synthetic analog of native somatostatin, inhibits growth hormone, glucagon, and insulin more potently.
    Octreotide acetate
  • HY-B1716
    L-5-Hydroxytryptophan
    3 Publications Verification

    L-5-HTP; Oxitriptan

    		 Endogenous Metabolite Neurological Disease Metabolic Disease
    L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia [5].
    L-5-Hydroxytryptophan
  • HY-125586
    β-Amanitin

    		DNA/RNA Synthesis ADC Payload Cancer
    β-Amanitin is a cyclic peptide toxin in the poisonous Amanita phalloides mushroom. β-Amanitin inhibits inhibits eukaryotic RNA polymerase II and III. β-Amanitin inhibits protein synthesis. β-Amanitin can be used as a cytotoxic component of antibody-drug conjugates (ADCs) .
    β-Amanitin
  • HY-B1716S
    L-5-Hydroxytryptophan-d3

    L-5-HTP-d3; Oxitriptan-d3

    		 Endogenous Metabolite Neurological Disease Metabolic Disease
    L-5-Hydroxytryptophan-d3 is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia [5].
    L-5-Hydroxytryptophan-d3
  • HY-B1716R
    L-5-Hydroxytryptophan (Standard)
    3 Publications Verification

    L-5-HTP (Standard); Oxitriptan (Standard)

    		 Endogenous Metabolite Reference Standards Neurological Disease Metabolic Disease
    L-5-Hydroxytryptophan (Standard) is the analytical standard of L-5-Hydroxytryptophan. This product is intended for research and analytical applications. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia [5].
    L-5-Hydroxytryptophan (Standard)
  • HY-108512
    PD 144418
    1 Publications Verification

    		 Sigma Receptor Neurological Disease
    PD 144418 is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 shows potential antipsychotic activity .
    PD 144418
  • HY-P10447
    Plipastatin A1

    Fengycin IX; SNA-60-367-3

    		 Phospholipase Fungal Infection
    Plipastatin A1 (Fengycin IX; SNA-60-367-3) is a lipopeptide with phospholipase A2 inhibitory activity. Plipastatin A1 inhibits conidial germination of Botrytis cinerea in vitro and reduces the incidence of gray mold on tomato leaves. Plipastatin A1 is applicable to research related to gray mold [1][2].
    Plipastatin A1
  • HY-N0122R
    5-Hydroxytryptophan (Standard)

    5-HTP (Standard); DL-5-Hydroxytryptophan (Standard)

    		 Endogenous Metabolite 5-HT Receptor Reference Standards Neurological Disease Metabolic Disease
    5-Hydroxytryptophan (Standard) is the analytical standard of 5-Hydroxytryptophan. This product is intended for research and analytical applications. 5-Hydroxytryptophan, a tryptophan metabolite, is a direct 5-hydroxytryptamine (5-HT) precursor and an L-aromatic amino acid decarboxylase substrate. .
    5-Hydroxytryptophan (Standard)
  • HY-B1716S2
    L-5-Hydroxytryptophan-d4

    L-5-HTP-d4; Oxitriptan-d4

    		 Isotope-Labeled Compounds Endogenous Metabolite Metabolic Disease
    L-5-Hydroxytryptophan-d4 (L-5-HTP-d4; Oxitriptan-d4) is a deuterium labeled L-5-Hydroxytryptophan (HY-B1716). L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia [5] .
    L-5-Hydroxytryptophan-d4
  • HY-W007328
    5-Methoxyindole

    		Endogenous Metabolite Drug Intermediate Inflammation/Immunology Cancer
    5-Methoxyindole is an endogenous compound with significant biological activity, which is produced by the metabolism of L-tryptophan. 5-Methoxyindole can be used as a drug intermediate to synthesize 5-methoxytryptophan and N-acetyl 5-methoxytryptamine, and it exhibits anti-cancer and anti-inflammatory activities.
    5-Methoxyindole
  • HY-101480
    Xylamidine

    		5-HT Receptor Neurological Disease
    Xylamidine is a peripheral 5-HT receptor antagonist used to investigate possible peripheral appetite suppressant effects of 5-hydroxytryptophan (5-HTP) and fenfluramine. In a 1-hour food intake test, xylamidine attenuated the decrease in food intake induced by 5-HT and 5-HTP, but had no effect on fenfluramine, suggesting that the appetite suppressant effect of 5-HTP is mediated in part through peripheral 5-HT receptors. Microstructural analysis revealed that 5-HTP and fenfluramine induced a decrease in food intake rate and a reduction in feeding batch size. Xylamidine reversed the effects of 5-HTP on food intake rate and induced a slight increase in feeding batch size itself, thus, the peripheral effect of 5-HTP appears to be to slow food intake rate. No effect of xylamidine on fenfluramine-induced changes in feeding was observed. The results suggest that the appetite suppressant effects of 5-HTP and fenfluramine are differentiated based on the peripheral effects of 5-HTP. The peripheral effects of 5-HTP are distinct from the previously reported 5-HT-induced decreases in feeding batch size and duration. Possible mechanisms underlying the differences in peripheral effects of 5-HT and 5-HTP are discussed.
    Xylamidine
  • HY-W007223
    D-5-Hydroxytryptophan

    D-5-HTP; 5-Hydroxy-D-tryptophan

    		 5-HT Receptor Neurological Disease
    D-5-Hydroxytryptophan (D-5-HTP) is the D-isomer of 5-HTP and can be isolated from DL-5-hydroxytryptophan by continuous separation. Compared with intraperitoneal administration of L-5-Hydroxytryptophan, which can induce dose-dependent backward walking behavior in mice, D-5-Hydroxytryptophan has no significant effect on mouse behavior and is a negative control. D-5-Hydroxytryptophan is also a 5-HT ligand, capable of binding to the 5-HT site with affinity in the micromolar range .
    D-5-Hydroxytryptophan
  • HY-108512A
    PD 144418 oxalate
    1 Publications Verification

    		 Sigma Receptor Neurological Disease
    PD 144418 oxalate is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 oxalate devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 oxalate shows potential antipsychotic activity .
    PD 144418 oxalate
  • HY-105328
    S-14489

    		5-HT Receptor Neurological Disease
    S-14489 is an orally active selective postsynaptic 5-HT1A receptor antagonist with a pKi of 9.2. S-14489 can act as a 5-HT1A autoreceptor agonist and inhibit striatal 5-hydroxytryptophan accumulation. S-14489 can be used for the research of neurological disease .
    S-14489
  • HY-P3100
    Orfamide A

    		Parasite Infection
    Orfamide A is a major metabolite of insecticidal biosurfactant in Pseudomonas sp. F6 and has aphidicidal activity. Orfamide A can be used for aphid control in organic agriculture. Orfamide A exhibits dose-dependent mortality against aphids with an LC50 value of 34.5 μg/mL .
    Orfamide A
  • HY-165624A
    (S)-LY-41

    		Drug Isomer Drug Derivative 5-HT Receptor Neurological Disease
    (S)-LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (S)-LY-41 is a potent and selective 5-HT1A receptor agonist. (S)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (S)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (S)-LY-41 can induce the 5-HT behavioral syndrome. (S)-LY-41can be used for the research of neurological disease, such as depression and anxiety .
    (S)-LY-41
  • HY-165624B
    (R)-LY-41

    		Drug Isomer Drug Derivative 5-HT Receptor Neurological Disease
    (R)-LY-41, R-enantiomer of LY-41 (HY-165624), is 2-Sminotetralin (HY-W022362) derivative and 8-OH-DPAT (HY-112061) analogue. (R)-LY-41 is a potent and selective 5-HT1A receptor agonist. (R)-LY-41 can reduce the accumulation of 5-hydroxytryptophan (the precursor for 5-HT synthesis) in the rat brain induced by decarboxylase inhibitors (NSD 1015). (R)-LY-41 can lower the body temperature of rats and inhibit the escape response from the cage. (R)-LY-41 can induce the 5-HT behavioral syndrome but is weaker than (S)-LY-41 (HY-165624A). (R)-LY-41 can be used for the research of neurological disease, such as depression and anxiety .
    (R)-LY-41
  • HY-B1716S1
    L-5-Hydroxytryptophan-d3-1

    L-5-HTP-d3-1; Oxitriptan-d3-1

    		 Endogenous Metabolite Metabolic Disease
    L-5-Hydroxytryptophan-d3-1 is the deuterium labeled L-5-Hydroxytryptophan . L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia [5] .
    L-5-Hydroxytryptophan-d3-1
  • HY-158104
    LPPM-8

    		ATF6 Others
    LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology .
    LPPM-8
  • HY-N19001
    (rac)-5-Hydroxykynurenine

    		Drug Metabolite Metabolic Disease
    (rac)-5-Hydroxykynurenine is a urinary metabolite. (rac)-5-Hydroxykynurenine is generated via indole ring oxidative cleavage of 5-hydroxytryptophan (HY-N0122) catalyzed by indoleamine 2,3-dioxygenase .
    (rac)-5-Hydroxykynurenine
  • HY-B1716SA
    L-5-Hydroxytryptophan-d3 hydrate

    L-5-HTP-d3 hydrate; Oxitriptan-d3 hydrate

    		 Isotope-Labeled Compounds Endogenous Metabolite Neurological Disease Metabolic Disease
    L-5-Hydroxytryptophan-d3 (L-5-HTP-d3) hydrate is the deuterium labeled L-5-Hydroxytryptophan (HY-B1716). L-5-Hydroxytryptophan-d3 is the deuterium labeled L-5-Hydroxytryptophan. L-5-Hydroxytryptophan (L-5-HTP), a naturally occurring amino acid and a dietary supplement for use as an antidepressant, appetite suppressant, and sleep aid, is the immediate precursor of the neurotransmitter serotonin and a reserpine antagonist . L-5-Hydroxytryptophan (L-5-HTP) is used to treat fibromyalgia, myoclonus, migraine, and cerebellar ataxia [5].
    L-5-Hydroxytryptophan-d3 hydrate
  • HY-P11783
    Surfactin C2

    		Fungal Infection
    Surfactin C2 is a lipopeptide produced by Bacillus subtilis A18 with antifungal activity. Surfactin C2 acts against Heterobasidion annosum and Heterobasidion parviporum. Surfactin C2 exerts its activity mainly through membrane‑active effects to disrupt fungal cell structures and inhibit mycelial growth. Surfactin C2 can be used for the research of butt rot and root rot of conifers .
    Surfactin C2
  • HY-P2209
    Nummularine B

    Daechuine S27; N-Demethylamphibine H

    		 Parasite Phosphodiesterase (PDE) Infection
    Nummularine B (Daechuine S27; N-Demethylamphibine H) is an anti-parasite agent. Nummularine B inhibits calmodulin-dependent phosphodiesterase activity with an IC50 of 16.8 μM. Nummularine B inhibits the growth of Plasmodium and Leishmania donovani in vitro. Nummularine B inhibits the calmodulin-dependent activity of actomyosin Ca 2+-ATPase. Nummularine B is applicable to research related to malaria and visceral leishmaniasis .
    Nummularine B
  • HY-P4948
    Coumarin-Phalloidin

    		Biochemical Assay Reagents Others
    Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton .
    Coumarin-Phalloidin

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