154130-99-1
154130-99-1
Chemical Structure
PD 144418
- CAS No.: 154130-99-1
- Formula:C18H22N2O
- Molecular Weight:282.38
IUPAC Name: 5-(1-propyl-1,2,5,6-tetrahydropyridin-3-yl)-3-(p-tolyl)isoxazole
InChIKey: FOQRKFCLRMMKAT-UHFFFAOYSA-N
SMILES: CCCN1CC(C2=CC(C3=CC=C(C)C=C3)=NO2)=CCC1
Biological Activity: PD 144418 is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 shows potential antipsychotic activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PD 144418 | 95.42% | PD 144418 is a highly affinity, potent and selective sigma 1 (σ1) receptor ligand (Ki values of 0.08 nM and 1377 nM for σ1 and σ2 respectively). PD 144418 devoids of any significant affinity for other receptors, ion channels and enzymes. PD 144418 shows potential antipsychotic activity. | ||||||||||||||||||||
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References
- [1]. Akunne HC, et al. The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology. 1997 Jan;36(1):51-62. [Content Brief]
- [2]. Lever JR, et al. Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418. J Pharmacol Exp Ther. 2014 Oct;351(1):153-63. [Content Brief]
Keywords
