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Isoforms Recommended:	ACSL4

Results for "

ACSL4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ACSL Family (16) Apoptosis (3) Bcl-2 Family (1) Caspase (1) COX (1) Endogenous Metabolite (1) ERK (3) Ferroptosis (11) Glutathione Peroxidase (7) IAP (1) Isotope-Labeled Compounds (1) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) NF-κB (3) PROTACs (1) Reactive Oxygen Species (ROS) (5) Reference Standards (1) Small Interfering RNA (siRNA) (3) TGF-beta/Smad (3) Transferrin Receptor (1)
By Research Areas:	Cancer (12) Inflammation/Immunology (5) Metabolic Disease (1) Neurological Disease (3)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

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Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: ACSL Family

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-173432

LIBX-A401	ACSL Family Ferroptosis	Neurological Disease Cancer
LIBX-A401 is a selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor with a human IC₅₀ values of 0.38 μM and a K_d of 0.72 μM. LIBX-A401 binds to ACSL4 in an ATP-dependent manner, stabilizes the C-terminal domain, alters the fatty acid gate region, and interacts with residues A329 and Q302 within the fatty acid binding site. LIBX-A401 exhibits anti-ferroptosis properties in cells. LIBX-A401 can be used for the researches of cancer and parkinson's disease .

HY-113167

2-Phosphoglyceric acid DL-2-phosphoglyceric acid	ACSL Family Endogenous Metabolite Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)	Metabolic Disease
2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP). 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating *ACSL4* and up-regulating *GPX4*, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell .

HY-175328

LIBX-A403	ACSL Family Ferroptosis	Neurological Disease Cancer
LIBX-A403 is a potent, selective and reversible *ACSL4* inhibitor with a human IC₅₀ of 0.049 μM and a K_d of 0.29 μM. LIBX-A403 binds in the ACSL4 fatty acid pocket in an ATP-dependent manner. LIBX-A403 prevents cell ferroptosis. LIBX-A403 can be used for the researches of cancer and parkinson's disease .

HY-RS16556

Acsl4 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) ACSL Family	Others
Acsl4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acsl4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acsl4 Mouse Pre-designed siRNA Set A Acsl4 Mouse Pre-designed siRNA Set A

HY-121246

Fluorofenidone 1 Publications Verification AKF-PD	ACSL Family NF-κB ERK TGF-beta/Smad	Inflammation/Immunology Cancer
Fluorofenidone (AKF-PD) is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of *ACSL4, upregulates GPX4* expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) .

HY-175327

LIBX-A402	ACSL Family Ferroptosis	Neurological Disease Cancer
LIBX-A402 is a selective, ATP-dependent inhibitor of *ACSL4* (hACSL4, IC₅₀=0.33 μM, K_d=3.3 μM) and an inhibitor of ferroptosis. LIBX-A402 targets the fatty acid-binding pocket of *ACSL4* and prevents cells from undergoing ferroptosis. LIBX-A402 can be used in the research of cancer and Parkinson's disease .

HY-RS00202

ACSL4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) ACSL Family	Others
ACSL4 Human Pre-designed siRNA Set A contains three designed siRNAs for ACSL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACSL4 Human Pre-designed siRNA Set A ACSL4 Human Pre-designed siRNA Set A

HY-115701

1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine; 15(S)-HpETE-SAPE; 15(S)-hydroperoxyeicostetraenoic acid-SAPE	Ferroptosis	Inflammation/Immunology
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.

HY-RS16244

Acsl4 Rat Pre-designed siRNA Set A	ACSL Family Small Interfering RNA (siRNA)	Others
Acsl4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Acsl4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acsl4 Rat Pre-designed siRNA Set A Acsl4 Rat Pre-designed siRNA Set A

HY-174345

Ferroptosis inducer-8	ACSL Family Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)	Cancer
Ferroptosis inducer-8 is a ferroptosis inducer with high selectivity for other cell death mechanism. Ferroptosis inducer-8 induces ferroptosis by affecting *ACSL4, GPX4, and FTH1, thereby disrupting intracellular iron homeostasis and the GSH/GPX4 antioxidant defense system, ultimately leading to the accumulation of lipid peroxidation. Ferroptosis inducer-8 also induces ROS* production. Ferroptosis inducer-8 inhibits tumor growth and can be used for research of triple-negative breast cancer (TNBC) .

HY-155852

Lepadin H	Ferroptosis Apoptosis ACSL Family Glutathione Peroxidase Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
Lepadin H is a ferroptosis inducer and apoptosis inducer with in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. Lepadin H reduces *GPX4* and SLC7A11 levels, increases p53 and *ACSL4* expression, drives lipid hydroperoxide production, elevates reactive oxygen species (ROS) levels, reduces cellular glutathione (GSH) levels, induces lipid peroxidation and G₂/M phase cell cycle arrest, and suppresses clonogenic growth and migration of cancer cells.Lepadin H can be used for the research of melanoma .

HY-179384

PROTAC FSP1 degrader 1	ACSL Family PROTACs Ferroptosis Glutathione Peroxidase Transferrin Receptor Reactive Oxygen Species (ROS)	Cancer
PROTAC FSP1 degrader 1 is a highly efficient and selective PROTAC degrader targeting FSP1. PROTAC FSP1 degrader 1 significantly induces the accumulation of intracellular lipid peroxides. PROTAC FSP1 degrader 1 exhibits synergistic induction of ferroptosis with GPX4 inhibitors. PROTAC FSP1 degrader 1 can induce ROS production. PROTAC FSP1 degrader 1 upregulates the mRNA expression of ferroptosis-related proteins (GPX4, FTH1, ACSL4, TfR1, FSP1). PROTAC FSP1 degrader 1 can be used for the study of triple-negative breast cancer .

HY-175698

Ferroptosis inducer-9	ACSL Family Ferroptosis Microtubule/Tubulin COX Glutathione Peroxidase	Cancer
Ferroptosis inducer-9 is a ferroptosis inducer and colchicine site tubulin polymerization inhibitor. Ferroptosis inducer-9 inhibits MCF-7 cell growth with an IC₅₀ of 14 nM and inhibits [ ³H]colchicine binding. Ferroptosis inducer-9 reduces expression of *GPX4* and FTH, increases COX2 and *ACSL4, lowers GSH, NADP+, and NADPH* levels, increases LPO, MDA, and Fe(II) levels, and decreases SOD concentrations. Ferroptosis inducer-9 demonstrates significant anti-tumor efficacy in HCT116 CRC xenograft model. Ferroptosis inducer-9 can be used for the study of triple negative breast cancer (TNBC) and colorectal cancer (CRC) .

HY-155851

Lepadin E	Ferroptosis MDM-2/p53 Glutathione Peroxidase ACSL Family	Cancer
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

HY-121246R

Fluorofenidone (Standard)	ACSL Family Reference Standards NF-κB ERK TGF-beta/Smad	Inflammation/Immunology
Fluorofenidone (Standard) is the analytical standard of Fluorofenidone (AKF-PD) (HY-121246). This product is intended for research and analytical applications. Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of *ACSL4, upregulates GPX4* expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) .

HY-121246S

Fluorofenidone-d3 AKF-PD-d₃	Isotope-Labeled Compounds ACSL Family NF-κB ERK TGF-beta/Smad	Inflammation/Immunology Cancer
Fluorofenidone-d₃ (AKF-PD-d3) is deuterium labeled Fluorofenidone (AKF-PD) (HY-121246). Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of *ACSL4, upregulates GPX4* expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) .

HY-183791A

Ferroptosis/apoptosis inducer-5	Ferroptosis Apoptosis Glutathione Peroxidase ACSL Family Reactive Oxygen Species (ROS) Mitochondrial Metabolism Caspase Bcl-2 Family	Cancer
Ferroptosis/apoptosis inducer-5 (Compound 14) is an orally active inducer of Ferroptosis and Apoptosis. Ferroptosis/apoptosis inducer-5 downregulates *GPX4, upregulates ACSL4, promotes ROS* production, activates the Caspase cascade, induces Mitochondrial dysfunction, and alters the Bcl-2/Bax balance. Ferroptosis/apoptosis inducer-5 significantly inhibits tumor growth in a pancreatic cancer xenograft mouse model. Ferroptosis/apoptosis inducer-5 can be used for the research of pancreatic cancer .

HY-182002

Apoptosis inducer 61	Apoptosis IAP	Cancer
Apoptosis inducer 61 (Compound 4E) is an Apoptosis inducer. Apoptosis inducer 61 significantly downregulates the expression of BIRC3 and activates Apoptosis. Anticancer agent 313 exhibits anticancer activity against ER ⁺ breast cancer cells, triple-negative breast cancer cells, and gastric cancer cells .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113167

2-Phosphoglyceric acid DL-2-phosphoglyceric acid	Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	ACSL Family Endogenous Metabolite Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)
2-Phosphoglyceric acid (DL-2-phosphoglyceric acid) is a glycolytic substrate that is catalyzed by enolase to form phosphoenolpyruvate ester (PEP). 2-Phosphoglyceric acid inhibits the ferroptosis pathway by down-regulating *ACSL4* and up-regulating *GPX4*, and has significant neuroprotective effects. 2-Phosphoglyceric acid reflects the overall metabolic state and flux of the cell .

HY-155852

Lepadin H	Structural Classification Alkaloids Animals Marine natural products Other marine organisms Quinoline Alkaloids Source Classification	Ferroptosis Apoptosis ACSL Family Glutathione Peroxidase Reactive Oxygen Species (ROS)
Lepadin H is a ferroptosis inducer and apoptosis inducer with in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. Lepadin H reduces *GPX4* and SLC7A11 levels, increases p53 and *ACSL4* expression, drives lipid hydroperoxide production, elevates reactive oxygen species (ROS) levels, reduces cellular glutathione (GSH) levels, induces lipid peroxidation and G₂/M phase cell cycle arrest, and suppresses clonogenic growth and migration of cancer cells.Lepadin H can be used for the research of melanoma .

HY-155851

Lepadin E	Structural Classification Alkaloids Animals Marine natural products Other marine organisms Quinoline Alkaloids Source Classification	Ferroptosis MDM-2/p53 Glutathione Peroxidase ACSL Family
Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .

Cat. No.	Product Name	Chemical Structure

HY-121246S

Fluorofenidone-d3
Fluorofenidone-d₃ (AKF-PD-d3) is deuterium labeled Fluorofenidone (AKF-PD) (HY-121246). Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of *ACSL4, upregulates GPX4* expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) .

Fluorofenidone-d3

Fluorofenidone-d₃ (AKF-PD-d3) is deuterium labeled Fluorofenidone (AKF-PD) (HY-121246). Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC) .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (1) IP (1) WB (2) ELISA (1)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal (2) Recombinant (1)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86465

	FACL4 Antibody (YA6157) Long-chain-fatty-acid--CoA ligase 4; Long-chain acyl-CoA synthetase 4; LACS 4; ACS4 antibody; ACSL 4 antibody; ACSL4 antibody	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	FACL4 Antibody (YA6157) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FACL4.

HY-P80977

	FACL4 Antibody (YA851) 1 Publications Verification ACS4; FACL4; LACS4; MRX63; MRX68	WB, IHC-P	Human, Mouse, Rat
	FACL4 Antibody (YA851) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to FACL4.

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Acsl4 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Acsl4 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acsl4 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

ACSL4 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
ACSL4 Human Pre-designed siRNA Set A contains three designed siRNAs for ACSL4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Acsl4 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Acsl4 Rat Pre-designed siRNA Set A contains three designed siRNAs for Acsl4 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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