2243423-32-5
Chemical Structure
Ferroptosis/apoptosis inducer-5
- CAS No.: 2243423-32-5
- Formula:C53H72BrO3P
- Molecular Weight:868.01
InChIKey: RHTBXEDWHDTGEF-AHOQDCQWSA-M
SMILES: O=C(OCCCCC[P+](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)[C@@]45CC[C@@]6(C)[C@]7(C)CC[C@@]8([H])C(C)(C)[C@@H](O)CC[C@]8(C)[C@@]7([H])CC[C@]6([H])[C@@]4([H])[C@H](C(C)=C)CC5.[Br-]
Biological Activity: Ferroptosis/apoptosis inducer-5 is an orally active inducer of Ferroptosis and Apoptosis. Ferroptosis/apoptosis inducer-5 downregulates GPX4, upregulates ACSL4, promotes ROS production, activates the Caspase cascade, induces Mitochondrial dysfunction, and alters the Bcl-2/Bax balance. Ferroptosis/apoptosis inducer-5 significantly inhibits tumor growth in a pancreatic cancer xenograft mouse model. Ferroptosis/apoptosis inducer-5 can be used for the research of pancreatic cancer[1].
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Ferroptosis/apoptosis inducer-5 | Ferroptosis/apoptosis inducer-5 is an orally active inducer of Ferroptosis and Apoptosis. Ferroptosis/apoptosis inducer-5 downregulates GPX4, upregulates ACSL4, promotes ROS production, activates the Caspase cascade, induces Mitochondrial dysfunction, and alters the Bcl-2/Bax balance. Ferroptosis/apoptosis inducer-5 significantly inhibits tumor growth in a pancreatic cancer xenograft mouse model. Ferroptosis/apoptosis inducer-5 can be used for the research of pancreatic cancer. | |||||||||||||||||||||
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