412328-25-7
Chemical Structure
Lepadin H
- CAS No.: 412328-25-7
- Formula:C26H45NO3
- Molecular Weight:419.64
InChIKey: RLTXIRPCJHXWEP-AFEGZDPGSA-N
SMILES: CCC[C@@H](O)CCCC[C@@H]1[C@@]2([H])[C@](CCC1)([H])N[C@H]([C@@H](C2)OC(/C=C/C=C/CCC)=O)C
Biological Activity: Lepadin H is a ferroptosis inducer and apoptosis inducer with in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. Lepadin H reduces GPX4 and SLC7A11 levels, increases p53 and ACSL4 expression, drives lipid hydroperoxide production, elevates reactive oxygen species (ROS) levels, reduces cellular glutathione (GSH) levels, induces lipid peroxidation and G2/M phase cell cycle arrest, and suppresses clonogenic growth and migration of cancer cells.Lepadin H can be used for the research of melanoma[1].
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Lepadin H | Lepadin H is a ferroptosis inducer and apoptosis inducer with in vitro cytotoxicity and in vivo antitumor efficacy against cancer cells. Lepadin H reduces GPX4 and SLC7A11 levels, increases p53 and ACSL4 expression, drives lipid hydroperoxide production, elevates reactive oxygen species (ROS) levels, reduces cellular glutathione (GSH) levels, induces lipid peroxidation and G2/M phase cell cycle arrest, and suppresses clonogenic growth and migration of cancer cells.Lepadin H can be used for the research of melanoma. | |||||||||||||||||||||
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