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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
20 Results for "
ALDH1A3
" in MedChemExpress (MCE) Product Catalog:
Products (20)
20 Results for "ALDH1A3" in MCE Product Catalog:
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ALDH1A inhibitor 673A is an ALDH1A inhibitor with IC50s of 246 nM (ALDH1A1), 230 nM (ALDH1A2), 348 nM (ALDH1A3), respectively. ALDH1A inhibitor 673A has little or no inhibitory effect on other ALDH family members. ALDH1A inhibitor 673A induces necroptotic ovarian cancer stem-like cells (CSCs) death. ALDH1A inhibitor 673A induces DNA double stand breaks in cancer cells. ALDH1A inhibitor 673A can be used for the study of ovarian cancer .
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1 Cited Publications
Cat. No.: HY-W015273A
CAS No.: 29953-71-7
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1 Cited Publications
Cat. No.: HY-W017186
CAS No.: 18962-05-5
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ALDH1A3-IN-3 is a potent inhibitor of ALDH1A3, with an IC50 of 0.26 μM. ALDH1A3-IN-3 is also a good ALDH3A1 substrate which limits its application as a selective inhibitor. ALDH1A3-IN-3 can be used for the research of prostate cancer .
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ALDH3A1-IN-3 (CB29) is a selective inhibitor of ALDH3A1, with a Ki value of 4.7 μM and an IC50 value of 16 μM. ALDH3A1-IN-3 has no inhibitory potential on the in vitro activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, or ALDH2. ALDH3A1-IN-3 can be used in cellular oxidation and cancer research .
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1 Cited Publications
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CM010 is a potent and selective aldehyde dehydrogenase 1A (ALDH1A) family inhibitor, with IC50s of 1700, 740, and 640 nM for ALDH1A1, ALDH1A2, and ALDH1A3, respectively. CM010 does not inhibit any of the other ALDH family members. CM010 can regulate metabolism and has anti-cancer activity .
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KOTX1 is an orally active and selective ALDH1A3 inhibitor. KOTX1 improves glucose tolerance, insulin secretion and blood sugar levels in diabetic mouse models .
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1 Cited Publications
Cat. No.: HY-169884
CAS No.: 1011366-31-6
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MCI-INI-3 is a selective ALDH1A3 inhibitor, with an IC50 of 0.46 μM and a Ki of 0.55 μM against hALDH1A3. MCI-INI-3 inhibits retinoic acid (HY-14649) biosynthesis. MCI-INI-3 can be used in research related to glioblastoma and glioma .
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ALDH1A3-IN-1 (Compound 14) is a potent ALDH1A3 inhibitor, with an IC50 of 0.63 μM and a Ki of 0.46 μM. ALDH1A3-IN-1 can be studied in prostate cancer .
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ALDH1A3-IN-2 (Compound 15) is a potent inhibitor of ALDH1A3 with an IC50 of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH1A3-IN-2 has the potential for the research of cancer diseases .
Cat. No.: HY-RS23346
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Aldh1a3 Rat Pre-designed siRNA Set A contains three designed siRNAs for Aldh1a3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W015273AR
CAS No.: 29953-71-7
Cat. No.: HY-RS00564
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ALDH1A3 Human Pre-designed siRNA Set A contains three designed siRNAs for ALDH1A3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS16904
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Aldh1a3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aldh1a3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-159111
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KS124 (compound 3) is a potent ALDH inhibitor. KS124 shows inhibition for ALDH1A1, ALDH1A3, ALDH3A1. KS124 shows antiproliferative activity. KS124 induces apoptosis and ROS production .
Cat. No.: HY-158026
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ALDH1A1-IN-5 (compound 25) is a potent aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitor with EC50 value of 83, 45, 43 µM for ALDH1A1, ALDH1A2, ALDH1A3, respectively. ALDH1A1-IN-5 has the potential for the research of high-grade serous ovarian cancer (HGSOC) .
Cat. No.: HY-169883
CAS No.: 1011641-78-3
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PKM2-IN-7 (compound 34) can inhibit the interaction between PKM2 and ALDH1A3 without showing significant toxicity to normal cells. PKM2-IN-7 can be used for research in the field of tumors .
Cat. No.: HY-128299
CAS No.: 324777-01-7
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ALDH3A1-IN-4 is a selective ALDH3A1 inhibitor with an IC50 of 0.2 μM. ALDH3A1-IN-4 binds to the aldehyde-binding pocket of ALDH3A1 via hydrophobic interactions and van der Waals forces. ALDH3A1-IN-4 acts as a chemosensitizer that sensitizes ALDH3A1-expressing cancer cells to the antiproliferative effect of mafosfamide, but does not produce a sensitizing effect on non-cancer cells that do not express ALDH3A1. ALDH3A1-IN-4 is applicable to research related to lung adenocarcinoma and glioblastoma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
