109437-62-9
Chemical Structure
ALDH1A inhibitor 673A
Synonym(s): ALDH1Ai 673A
- CAS No.: 109437-62-9
- Formula:C15H13NO
- Molecular Weight:223.27
IUPAC Name: 4-(isoindolin-2-yl)benzaldehyde
InChIKey: GSAVXYHVHQTGEA-UHFFFAOYSA-N
SMILES: O=CC1=CC=C(N2CC3=C(C=CC=C3)C2)C=C1
Biological Activity: ALDH1A inhibitor 673A is an ALDH1A inhibitor with IC50s of 246 nM (ALDH1A1), 230 nM (ALDH1A2), 348 nM (ALDH1A3), respectively. ALDH1A inhibitor 673A has little or no inhibitory effect on other ALDH family members. ALDH1A inhibitor 673A induces necroptotic ovarian cancer stem-like cells (CSCs) death. ALDH1A inhibitor 673A induces DNA double stand breaks in cancer cells. ALDH1A inhibitor 673A can be used for the study of ovarian cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ALDH1A inhibitor 673A | 99.15% | ALDH1A inhibitor 673A is an ALDH1A inhibitor with IC50s of 246 nM (ALDH1A1), 230 nM (ALDH1A2), 348 nM (ALDH1A3), respectively. ALDH1A inhibitor 673A has little or no inhibitory effect on other ALDH family members. ALDH1A inhibitor 673A induces necroptotic ovarian cancer stem-like cells (CSCs) death. ALDH1A inhibitor 673A induces DNA double stand breaks in cancer cells. ALDH1A inhibitor 673A can be used for the study of ovarian cancer. | ||||||||||||||||||||
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- [1]. McGonigal S, et al. A putative role for ALDH inhibitors and chemoprevention of BRCA-mutation-driven tumors. Gynecol Oncol. 2023 Sep;176:139-146. [Content Brief]
- [2]. Grimley E, et al. Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors. Theranostics. 2021 Jan 20;11(8):3540-3551. [Content Brief]
- [3]. Chefetz I, et al. A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells. Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. [Content Brief]
Keywords
