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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
ATF2
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "ATF2" in MCE Product Catalog:
17
17 Publications Verification
Synonyms: LY2228820 dimesylate
Research Areas:
Ralimetinib dimesylate (LY2228820 dimesylate) is a selective, ATP-competitive inhibitor of p38 MAPK α/β with IC50s of 5.3 and 3.2 nM, respectively. Ralimetinib (LY2228820) selectively inhibits phosphorylation of MK2 (Thr334), with no effect on phosphorylation of p38a MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc.
17
Ralimetinib is an ATP-competitive p38α and p38β MAPK inhibitor with an IC50 of 5.3 nmol/L against human p38α and an IC50 of 3.2 nmol/L against human p38β. Ralimetinib slows tumor growth in preclinical in vivo cancer models, exhibits oral bioavailability in mice, and achieves sustained target inhibition for 4 to 8 h. Ralimetinib is applicable for research on melanoma, non-small cell lung cancer, ovarian cancer, glioma, multiple myeloma, breast cancer, renal cancer, and head and neck squamous cell carcinoma [2].
5
1
Target:
Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice [2] .
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Synonyms: HRX-0215
Darizmetinib (HRX-0215) is an orally active, potent and selective inhibitor of mitogen-activated protein kinase kinase 4 (MKK4). Darizmetinib leads to enhancement of the MKK7 and JNK1 signaling pathways, thereby activating the transcription factors ATF2 and ELK1, promoting cell proliferation and liver regeneration. Darizmetinib is promising for research of preventing liver failure after extensive oncological liver resections or transplantation of small liver grafts [2] .
Cat. No.: HY-134963
CAS No.: 864431-36-7
SBI-0087702 promots the cytoplasmic localization of ATF2 in melanoma cells. SBI-0087702-induced translocation of ATF2 to the mitochondria results in increased apoptosis due to loss of mitochondrial membrane integrity. SBI-0087702 also inhibits growth and motility of melanoma cells. SBI-0087702 was shown to inhibit ATF2 phosphorylation on Thr52 by PKCε .
Cat. No.: HY-RS17003
Target:
Research Areas:
Atf2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atf2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Synonyms: N-(Hydroxymethyl)thalidomide
Research Areas:
CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines [2] .
Cat. No.: HY-RS01128
Target:
Research Areas:
ATF2 Human Pre-designed siRNA Set A contains three designed siRNAs for ATF2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23446
Target:
Research Areas:
Atf2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Atf2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Target:
Piperonyl butoxide (Standard) is the analytical standard of Piperonyl butoxide. This product is intended for research and analytical applications. Piperonyl butoxide (ENT-14250) is a pesticide synergist and food additive. Piperonyl butoxide has adverse effects on reproduction, development and behavior in mice. Piperonyl butoxide can activate c-Jun and ATF-2 in mouse hepatocytes. Piperonyl butoxide is a liver cancer carcinogen in rats and mice [2] .
Cat. No.: HY-B1198S
CAS No.: 1329834-53-8
Synonyms: ENT-14250-d9
Cat. No.: HY-P74408
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: Activating transcription factor 2; ATF2; CREB2; HB16
Species:
Source:
Cat. No.: HY-P85048
Synonyms: ATF2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding pro
Cat. No.: HY-P80552
Synonyms: Activating transcription factor 2 antibody;
Activating transcription factor 2 splice variant ATF2 var2 antibody;
ATF 2 antibody;
ATF-2 antibody;
ATF2 antibody;
ATF2 protein antibody;
ATF2_HUMAN antibody;
cAMP Response Element Binding Protein 2 antibody;
cAMP response element binding protein CRE BP1 antibody;
cAMP response element-binding protein CRE-BP1 antibody;
cAMP responsive element binding protein 2, formerly antibody;
cAMP-dependent transcription factor ATF-2 antibody;
cAMP-responsive element-binding protein 2 antibody;
CRE BP1 antibody;
CRE-BP antibody;
CREB 2 antibody;
CREB-2 antibody;
CREB2 antibody;
CREBP1 antibody;
Cyclic AMP dependent transcription factor ATF 2 antibody;
Cyclic AMP-dependent transcription factor ATF-2 antibody;
Cyclic AMP-responsive element-binding protein 2 antibody;
D130078H02Rik antibody;
D18875 antibody;
HB 16 antibody;
HB16 antibody;
Histone acetyltransferase ATF2 antibody;
MGC105211 antibody;
MGC105222 antibody;
MGC111558 antibody;
MGC142504 antibody;
mXBP antibody;
MXBP protein antibody;
Tg(Gzma-Klra1)7Wum antibody;
TREB 7 antibody;
TREB7 antibody
Cat. No.: HY-P80793
Synonyms: ATF2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding pro
Cat. No.: HY-P80793A
Synonyms: ATF2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; cAMP-dependent transcription factor ATF-2; Activating transcription factor 2; Cyclic AMP-responsive element-binding protein 2; CREB-2; cAMP-responsive element-binding pro
Cat. No.: HY-P80552A
Synonyms: Activating transcription factor 2 antibody;
Activating transcription factor 2 splice variant ATF2 var2 antibody;
ATF 2 antibody;
ATF-2 antibody;
ATF2 antibody;
ATF2 protein antibody;
ATF2_HUMAN antibody;
cAMP Response Element Binding Protein 2 antibody;
cAMP response element binding protein CRE BP1 antibody;
cAMP response element-binding protein CRE-BP1 antibody;
cAMP responsive element binding protein 2, formerly antibody;
cAMP-dependent transcription factor ATF-2 antibody;
cAMP-responsive element-binding protein 2 antibody;
CRE BP1 antibody;
CRE-BP antibody;
CREB 2 antibody;
CREB-2 antibody;
CREB2 antibody;
CREBP1 antibody;
Cyclic AMP dependent transcription factor ATF 2 antibody;
Cyclic AMP-dependent transcription factor ATF-2 antibody;
Cyclic AMP-responsive element-binding protein 2 antibody;
D130078H02Rik antibody;
D18875 antibody;
HB 16 antibody;
HB16 antibody;
Histone acetyltransferase ATF2 antibody;
MGC105211 antibody;
MGC105222 antibody;
MGC111558 antibody;
MGC142504 antibody;
mXBP antibody;
MXBP protein antibody;
Tg(Gzma-Klra1)7Wum antibody;
TREB 7 antibody;
TREB7 antibody
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
