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AZ521

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By Targets:	Apoptosis (2) Caspase (1) Drug Derivative (3) EBV (1) Endogenous Metabolite (1) NO Synthase (1)
By Research Areas:	Cancer (6) Infection (1) Inflammation/Immunology (1)

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Natural
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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122919

Momordicoside L	Endogenous Metabolite	Cancer
Momordicoside L is a Cucurbitane Triterpenoid, that can be isolated from the leaves of Momordica charantia. Momordicoside L shows anticancer activity .

HY-N1710

28-Deoxonimbolide	Apoptosis Caspase	Cancer
28-Deoxonimbolide is a Nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways .

HY-N10091

2,3-Dihydro-3α-methoxynimbolide	Apoptosis	Others
2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521 .

HY-N18321

3-Deacetyl-4-demethylsalannin	Drug Derivative	Cancer
3-Deacetyl-4-demethylsalannin, a salannin-type limonoid, is an anticancer agent. 3-Deacetyl-4-demethylsalannin induces cytotoxic activity against leukemia cells and stomach cancer cells, and shows inactivity against lung and breast cancer cells at concentrations up to 100 μM. 3-Deacetyl-4-demethylsalannin can be used for the research of leukemia, stomach cancer .

HY-N18117A

23-Hydroxyohchininolide	NO Synthase EBV	Infection Inflammation/Immunology Cancer
23-Hydroxyohchininolide is a limonoid found in the leaves of Melia azedarach L.. 23-Hydroxyohchininolide inhibits LPS (HY-D1056)-induced NO production and exerts cytotoxic activity against human leukemia and stomach cancer cells. 23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen activation. 23-Hydroxyohchininolide can be used for the research of cancer, infection and inflammatory disease .

HY-N18214

3-Deacetyl-1,6-diacetylsendanal	Drug Derivative	Cancer
3-Deacetyl-1,6-diacetylsendanal is a limonoid compound isolated from the fruits of Melia azedarach. 3-Deacetyl-1,6-diacetylsendanal reduces the viability of leukemia and gastric cancer cells. 3-Deacetyl-1,6-diacetylsendanal can be used in research related to leukemia and gastric cancer .

HY-N18115

3-O-Deacetyl-3-O-tigloylsalannin	Drug Derivative	Cancer
3-O-Deacetyl-3-O-tigloylsalannin is a salannin-type limonoid and cytotoxic agent found in the fruits of Melia azedarach. 3-O-Deacetyl-3-O-tigloylsalannin can be used for the research of leukemia, stomach cancer, breast cancer .

Momordicoside L	Triterpenes Terpenoids Cucurbitaceae Plants Momordica charantia Linn. Source Classification	Endogenous Metabolite
Momordicoside L is a Cucurbitane Triterpenoid, that can be isolated from the leaves of Momordica charantia. Momordicoside L shows anticancer activity .

28-Deoxonimbolide	Triterpenes Terpenoids Azadirachta indica A. Juss. Plants Meliaceae Source Classification	Apoptosis Caspase
28-Deoxonimbolide is a Nimbin (HY-N3187) type limonoid, that can be isolated from Azadirachta indica seed extracts. 28-Deoxonimbolide shows anticancer activity. 28-Deoxonimbolide induces apoptotic cell death in HL60 cells via both the mitochondrial- and the death receptor-mediated pathways .

3-Deacetyl-4-demethylsalannin	Structural Classification Natural Products Melia azedarach Linn. Plants Meliaceae Source Classification	Drug Derivative
3-Deacetyl-4-demethylsalannin, a salannin-type limonoid, is an anticancer agent. 3-Deacetyl-4-demethylsalannin induces cytotoxic activity against leukemia cells and stomach cancer cells, and shows inactivity against lung and breast cancer cells at concentrations up to 100 μM. 3-Deacetyl-4-demethylsalannin can be used for the research of leukemia, stomach cancer .

23-Hydroxyohchininolide	Structural Classification Terpenoids Melia azedarach L. Diterpenoids Plants Meliaceae Source Classification	NO Synthase EBV
23-Hydroxyohchininolide is a limonoid found in the leaves of Melia azedarach L.. 23-Hydroxyohchininolide inhibits LPS (HY-D1056)-induced NO production and exerts cytotoxic activity against human leukemia and stomach cancer cells. 23-Hydroxyohchininolide inhibits TPA (HY-18739)-induced Epstein-Barr virus early antigen activation. 23-Hydroxyohchininolide can be used for the research of cancer, infection and inflammatory disease .

3-Deacetyl-1,6-diacetylsendanal	Structural Classification Melia azedarach Linn. Plants Meliaceae Steroids Source Classification	Drug Derivative
3-Deacetyl-1,6-diacetylsendanal is a limonoid compound isolated from the fruits of Melia azedarach. 3-Deacetyl-1,6-diacetylsendanal reduces the viability of leukemia and gastric cancer cells. 3-Deacetyl-1,6-diacetylsendanal can be used in research related to leukemia and gastric cancer .

3-O-Deacetyl-3-O-tigloylsalannin	Structural Classification Terpenoids Melia azedarach L. Diterpenoids Plants Meliaceae Source Classification	Drug Derivative
3-O-Deacetyl-3-O-tigloylsalannin is a salannin-type limonoid and cytotoxic agent found in the fruits of Melia azedarach. 3-O-Deacetyl-3-O-tigloylsalannin can be used for the research of leukemia, stomach cancer, breast cancer .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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AZ521

Inhibitors & Agonists

NaturalProducts

Natural
Products