1607828-35-2
Chemical Structure
2,3-Dihydro-3α-methoxynimbolide
- CAS No.: 1607828-35-2
- Formula:C28H34O8
- Molecular Weight:498.56
InChIKey: OROAUBFPFAPQMD-LPLKPKLGSA-N
SMILES: C[C@@]12[C@@](O[C@@]3([H])C2=C([C@@](C4=COC=C4)([H])C3)C)([H])[C@@]5([H])[C@]6([H])[C@@]([C@H]1CC(OC)=O)(C(C[C@H]([C@]6(C(O5)=O)C)OC)=O)C
Biological Activity: 2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521[1].
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2,3-Dihydro-3α-methoxynimbolide | 2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521. | |||||||||||||||||||||
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