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  3. Drug Derivative
  4. 3-Deacetyl-4-demethylsalannin

3-Deacetyl-4-demethylsalannin, a salannin-type limonoid, is an anticancer agent. 3-Deacetyl-4-demethylsalannin induces cytotoxic activity against leukemia cells and stomach cancer cells, and shows inactivity against lung and breast cancer cells at concentrations up to 100 μM. 3-Deacetyl-4-demethylsalannin can be used for the research of leukemia, stomach cancer.

For research use only. We do not sell to patients.

3-Deacetyl-4-demethylsalannin

3-Deacetyl-4-demethylsalannin Chemical Structure

CAS No. : 1621682-24-3

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3-Deacetyl-4-demethylsalannin Related Antibodies

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Description

3-Deacetyl-4-demethylsalannin, a salannin-type limonoid, is an anticancer agent. 3-Deacetyl-4-demethylsalannin induces cytotoxic activity against leukemia cells and stomach cancer cells, and shows inactivity against lung and breast cancer cells at concentrations up to 100 μM. 3-Deacetyl-4-demethylsalannin can be used for the research of leukemia, stomach cancer[1].

In Vitro

3-Deacetyl-4-demethylsalannin (1-100 μM; 48 h) exhibits cytotoxic activity against HL60 and AZ521 human cancer cells with IC50 values of 9.6±1.2 μM and 47.5±3.6 μM, respectively, and no cytotoxic activity against A549 or SK-BR-3 human cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Deacetyl-4-demethylsalannin Related Antibodies

Cell Proliferation Assay[1]

Cell Line: Human HL60 (leukemia), A549 (lung), AZ521 (stomach), SK-BR-3 (breast) cancer cell lines
Concentration: 1-100 μM
Incubation Time: 48 h
Result: Exhibited cytotoxic activity against HL60 cells with an IC50 of 9.6 μM.
Exhibited cytotoxic activity against AZ521 cells with an IC50 of 47.5 μM.
Showed no cytotoxic activity (IC50 >100 μM) against A549 and SK-BR-3 cells.
Molecular Weight

540.64

Formula

C31H40O8
CAS No.
SMILES

C[C@@]12[C@@](O[C@@]3([H])C2=C([C@H](C4=COC=C4)C3)C)([H])[C@@]5([H])[C@]6([H])[C@@]([C@H]1CC(OC)=O)([C@H](C[C@H]([C@]6(CO5)C)O)OC(C(C)=C)=O)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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3-Deacetyl-4-demethylsalannin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Deacetyl-4-demethylsalannin1621682-24-3Drug DerivativeDrug derivativeleukemialeukemia cellsHL60A549stomach cancerMelia azedarach L.lung cancer cellsbreast cancer cellsAZ521stomach cancer cellsInhibitorinhibitorinhibit

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