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Cat. No.: HY-N18321

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3-Deacetyl-4-demethylsalannin

3-Deacetyl-4-demethylsalannin, a salannin-type limonoid, is an anticancer agent. 3-Deacetyl-4-demethylsalannin induces cytotoxic activity against leukemia cells and stomach cancer cells, and shows inactivity against lung and breast cancer cells at concentrations up to 100 μM. 3-Deacetyl-4-demethylsalannin can be used for the research of leukemia, stomach cancer.

For research use only. We do not sell to patients.

CAS No.: 1621682-24-3
Formula: C₃₁H₄₀O₈
Molecular Weight:540.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

3-Deacetyl-4-demethylsalannin Chemical Structure

CAS No.: 1621682-24-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

3-Deacetyl-4-demethylsalannin (1-100 μM; 48 h) exhibits cytotoxic activity against HL60 and AZ521 human cancer cells with IC₅₀ values of 9.6±1.2 μM and 47.5±3.6 μM, respectively, and no cytotoxic activity against A549 or SK-BR-3 human cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Human HL60 (leukemia), A549 (lung), AZ521 (stomach), SK-BR-3 (breast) cancer cell lines
Concentration:

1-100 μM
Incubation Time:

48 h
Result:

Exhibited cytotoxic activity against HL60 cells with an IC₅₀ of 9.6 μM.
Exhibited cytotoxic activity against AZ521 cells with an IC₅₀ of 47.5 μM.
Showed no cytotoxic activity (IC₅₀ >100 μM) against A549 and SK-BR-3 cells.

Chemical Information

CAS No. 1621682-24-3
Molecular Weight 540.64
Formula C₃₁H₄₀O₈
SMILES

C[C@@]12[C@@](O[C@@]3([H])C2=C([C@H](C4=COC=C4)C3)C)([H])[C@@]5([H])[C@]6([H])[C@@]([C@H]1CC(OC)=O)([C@H](C[C@H]([C@]6(CO5)C)O)OC(C(C)=C)=O)C
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Pan X, et al. Three new and other limonoids from the hexane extract of Melia azedarach fruits and their cytotoxic activities. Chem Biodivers. 2014;11(7):987-1000. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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