3-Deacetyl-4-demethylsalannin

Cat. No.: HY-N18321: Data Sheet Handling Instructions
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3-Deacetyl-4-demethylsalannin, a salannin-type limonoid, is an anticancer agent. 3-Deacetyl-4-demethylsalannin induces cytotoxic activity against leukemia cells and stomach cancer cells, and shows inactivity against lung and breast cancer cells at concentrations up to 100 μM. 3-Deacetyl-4-demethylsalannin can be used for the research of leukemia, stomach cancer.

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3-Deacetyl-4-demethylsalannin 화학구조

CAS No. : 1621682-24-3

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

In Vitro

3-Deacetyl-4-demethylsalannin (1-100 μM; 48 h) exhibits cytotoxic activity against HL60 and AZ521 human cancer cells with IC₅₀ values of 9.6±1.2 μM and 47.5±3.6 μM, respectively, and no cytotoxic activity against A549 or SK-BR-3 human cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Human HL60 (leukemia), A549 (lung), AZ521 (stomach), SK-BR-3 (breast) cancer cell lines
Concentration:	1-100 μM
Incubation Time:	48 h
Result:	Exhibited cytotoxic activity against HL60 cells with an IC₅₀ of 9.6 μM. Exhibited cytotoxic activity against AZ521 cells with an IC₅₀ of 47.5 μM. Showed no cytotoxic activity (IC₅₀ >100 μM) against A549 and SK-BR-3 cells.

분자량

540.64

화학식

C₃₁H₄₀O₈

CAS No.

1621682-24-3

SMILES

C[C@@]12[C@@](O[C@@]3([H])C2=C([C@H](C4=COC=C4)C3)C)([H])[C@@]5([H])[C@]6([H])[C@@]([C@H]1CC(OC)=O)([C@H](C[C@H]([C@]6(CO5)C)O)OC(C(C)=C)=O)C

Structure Classification

Others

Initial Source

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Pan X, et al. Three new and other limonoids from the hexane extract of Melia azedarach fruits and their cytotoxic activities. Chem Biodivers. 2014;11(7):987-1000. [Content Brief]