7 Results for "

Anion secretion

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "Anion secretion" in MCE Product Catalog:

2
Tryptamine
Tryptamine
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2 Cited Publications
Cat. No.: HY-B2132
CAS No.: 61-54-1
Synonyms: 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine
Category:  

Alkaloids Microorganisms Other Diseases Endogenous metabolite Disease Research Fields Indole Alkaloids

Target:  

Endogenous Metabolite 5-HT Receptor Aryl Hydrocarbon Receptor

Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models .
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4-Pyridoxic acid
4-Pyridoxic acid
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Cat. No.: HY-113493
CAS No.: 82-82-6
Purity:  99.82%
Category:  

Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields

Target:  

Endogenous Metabolite

4-Pyridoxic acid is an endogenous substrate of renal organic anion transporters (OAT1/3) and a catabolite of vitamin B6. 4-Pyridoxic acid is excreted through OAT1/3-mediated tubular active secretion, which can reflect OAT1/3 activity. Elevated plasma concentrations of 4-Pyridoxic acid are associated with decreased OAT1/3 activity in chronic kidney disease (CKD) and can be used as a biomarker to reflect the severity of knee osteoarthritis (KOA) and lumbar spondylosis (LS) .
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Neltenexine
Neltenexine
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Cat. No.: HY-165407
CAS No.: 99453-84-6
Target:  

Elastase CFTR

Research Areas:  

Inflammation/Immunology

Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research .
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AP-C4
AP-C4
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Cat. No.: HY-153540
CAS No.: 682794-85-0
Target:  

PKG

Research Areas:  

Others

AP-C4 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 5.2. AP-C3 does not inhibit cGKII-dependent anion secretion .
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AP-C7
AP-C7
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Cat. No.: HY-153541
CAS No.: 2234275-84-2
Target:  

PKG

Research Areas:  

Others

AP-C7 is an inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 5.0. AP-C7 only weakly inhibits cGKII-dependent anion secretion .
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AP-C1
AP-C1
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Cat. No.: HY-153537
CAS No.: 2234280-26-1
Target:  

PKG

Research Areas:  

Others

AP-C1 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 6.5. AP-C1 only weakly inhibits cGKII-dependent anion secretion .
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AP-C3
AP-C3
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Cat. No.: HY-153539
CAS No.: 682795-78-4
Target:  

PKG

Research Areas:  

Others

AP-C3 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 6.3. AP-C3 only weakly inhibits cGKII-dependent anion secretion .
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