61-54-1
Chemical Structure
Tryptamine
Synonym(s): 3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine
- CAS. Nr.: 61-54-1
- Formula:C10H12N2
- Molecular Weight:160.22
IUPAC Name: 2-(1H-indol-3-yl)ethan-1-amine
InChIKey: APJYDQYYACXCRM-UHFFFAOYSA-N
SMILES: NCCC1=CNC2=C1C=CC=C2
Biological Activity: Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models[1][2][3].
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Tryptamine | 99.95% | Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models. | ||||||||||||||||||||
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Tryptamine (Standard) | 97.84% | Tryptamine (Standard) is the analytical standard of Tryptamine. This product is intended for research and analytical applications. Tryptamine is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter. | ||||||||||||||||||||
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Tryptamine-d2 hydrochloride | Tryptamine-d2 (hydrochloride) is a deuterium labeled Tryptamine hydrochloride. Tryptamine hydrochloride is a monoamine alkaloid, similar to other trace amines, is believed to play a role as a neuromodulator or neurotransmitter. | |||||||||||||||||||||
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References
- [1]. Jones RS, et al. Tryptamine: a neuromodulator or neurotransmitter in mammalian brain? Prog Neurobiol. 1982;19(1-2):117-39. [Content Brief]
- [2]. Dopkins N, et al. Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor. Front Pharmacol. 2021 Jan 25;11:619265. [Content Brief]
- [3]. Bhattarai Y, et al. Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion. Cell Host Microbe. 2018 Jun 13;23(6):775-785.e5. [Content Brief]
