Search Result

Isoforms Recommended:	CRFR2

Results for "

CRFR2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CRFR (11) Reference Standards (1) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cardiovascular Disease (4) Endocrinology (5) Inflammation/Immunology (2) Metabolic Disease (2) Neurological Disease (7)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Oligonucleotides

Targets Recommended: CRFR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2847

Urocortin II, mouse	CRFR	Metabolic Disease Endocrinology
Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with K_i values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca ²⁺/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow ^[2] .

HY-P1108A

Astressin 2B TFA 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective *CRFR2* antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 ^[2] .

HY-P1108

Astressin 2B 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B is a blood-brain barrier-impermeable, highly selective *CRFR2* antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 ^[2] .

HY-P1858A

Urocortin III, mouse TFA	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates *CRF-R2* . Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics ^[2].

HY-135542

NBI-27914 2 Publications Verification	CRFR	Others
NBI-27914 is a highly selective, high-affinity non-peptide competitive antagonist of human corticotropin-releasing factor receptor 1 (CRFR1). NBI-27914 primarily binds to the His199 and Met276 sites in the transmembrane domain of the receptor ^[2].

HY-P1858

Urocortin III, mouse	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Urocortin III, mouse is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates *CRF-R2* . Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics ^[2].

HY-P3019

Urocortin III (human)	CRFR	Cardiovascular Disease Neurological Disease Endocrinology
Urocortin III (human) is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) preferentially binds and activates *CRF-R2* and has a discrete central nervous system and peripheral distribution. Urocortin III (human) potently binds to type 2 CRF receptors, specifically *mCRF_2β* (K_i = 13.5 nM) and *rCRF_2α* (K_i = 21.7 nM), while demonstrating negligible affinity for hCRF1 (K_i >100 nM). Urocortin III (human) mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion ^[1][2].

HY-P3019A

Urocortin III (human) TFA	CRFR	Cardiovascular Disease Neurological Disease Metabolic Disease
Urocortin III (human) TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III (human) TFA preferentially binds and activates *CRF-R2* and has a discrete central nervous system and peripheral distribution. Urocortin III (human) TFA potently binds to type 2 CRF receptors, specifically *mCRF_2β* (K_i = 13.5 nM) and *rCRF_2α* (K_i = 21.7 nM), while demonstrating negligible affinity for hCRF1 (K_i >100 nM). Urocortin III (human) TFA mediates somatostatin-dependent negative feedback control of Insulin (human) (HY-P0035) secretion ^[2].

HY-P3959

(Tyr0)-Urocortin, rat	CRFR	Endocrinology
(Tyr0)-Urocortin, rat is a high-affinity agonist of corticotropin-releasing factor receptor type 1 (CRF-R1) and type 2 (CRF-R2). (Tyr0)-Urocortin, rat shows inhibitory binding constants (Ki) of 1-2 nM .

HY-RS03172

Crhr2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Crhr2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Crhr2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Crhr2 Mouse Pre-designed siRNA Set A Crhr2 Mouse Pre-designed siRNA Set A

HY-RS03171

CRHR2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CRHR2 Human Pre-designed siRNA Set A contains three designed siRNAs for CRHR2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CRHR2 Human Pre-designed siRNA Set A CRHR2 Human Pre-designed siRNA Set A

HY-135542R

NBI-27914 (Standard)	CRFR Reference Standards	Others
NBI-27914 (Standard) is the analytical standard of NBI-27914 (HY-135542). This product is intended for research and analytical applications. NBI-27914 is a highly selective, high-affinity non-peptide competitive antagonist of human corticotropin-releasing factor receptor 1 (CRFR1). NBI-27914 primarily binds to the His199 and Met276 sites in the transmembrane domain of the receptor.

HY-103375

SN003	CRFR	Neurological Disease
SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC₅₀ = 241 nM) that displays more than 1000-fold selectivity over *CRFR* 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat ^[2] .

HY-RS03173

Crhr2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Crhr2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Crhr2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Crhr2 Rat Pre-designed siRNA Set A Crhr2 Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area