184241-44-9
184241-44-9
Chemical Structure
NBI-27914
- CAS No.: 184241-44-9
- Formula:C18H20Cl4N4
- Molecular Weight:434.19
IUPAC Name: 5-chloro-N4-(cyclopropylmethyl)-2-methyl-N4-propyl-N6-(2,4,6-trichlorophenyl)pyrimidine-4,6-diamine
InChIKey: KNADXBVKFAUMCR-UHFFFAOYSA-N
SMILES: ClC1=C(NC2=C(Cl)C(N(CC3CC3)CCC)=NC(C)=N2)C(Cl)=CC(Cl)=C1
Biological Activity: NBI-27914 is a highly selective, high-affinity non-peptide competitive antagonist of human corticotropin-releasing factor receptor 1 (CRFR1). NBI-27914 primarily binds to the His199 and Met276 sites in the transmembrane domain of the receptor[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NBI-27914 | 99.94% | NBI-27914 is a highly selective, high-affinity non-peptide competitive antagonist of human corticotropin-releasing factor receptor 1 (CRFR1). NBI-27914 primarily binds to the His199 and Met276 sites in the transmembrane domain of the receptor. | ||||||||||||||||||||
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NBI-27914 (Standard) | ≥98% | NBI-27914 (Standard) is the analytical standard of NBI-27914 (HY-135542). This product is intended for research and analytical applications. NBI-27914 is a highly selective, high-affinity non-peptide competitive antagonist of human corticotropin-releasing factor receptor 1 (CRFR1). NBI-27914 primarily binds to the His199 and Met276 sites in the transmembrane domain of the receptor. | ||||||||||||||||||||
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References
- [1]. Liaw CW, et al. Localization of agonist- and antagonist-binding domains of human corticotropin-releasing factor receptors. Mol Endocrinol. 1997;11(13):2048-2053. [Content Brief]
- [2]. Nakazato A, et al. Corticotropin-releasing factor1 receptor as a target for therapeutic intervention[J]. Drugs of the Future, 1999, 24(10).
Keywords
