2. GPCR/G Protein
  3. CRFR
  4. Urocortin II, mouse

Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with Ki values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow.

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Urocortin II, mouse Chemical Structure

Urocortin II, mouse Chemical Structure

CAS No. : 330648-32-3

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Urocortin II, mouse Related Antibodies

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Description

Urocortin II, mouse is a potent and selective endogenous peptide agonist of type-2 corticotropin-releasing factor (CRF2) receptor with Ki values of 0.66 nM and ﹥100 nM for CRFR2 and CRFR1, respectively. Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca2+/CaMKII-dependent manner.Urocortin II, mouse is expressed in discrete areas of the central nervous system, and activates central neurons involved in the processing of visceral sensory information, and in modulating autonomic outflow[1][2][3].

IC50 & Target[2]

CRFR2

0.66 nM (Ki)

CRFR1

﹥100 nM (Ki)

In Vitro

Urocortin II, mouse elicits positive inotropic and positive lusitropic effects in mouse ventricular myocytes via activation of CRF2 receptors[1].
Urocortin II, mouse activates CRF2 receptors in a cAMP/PKA- and Ca2+/CaMKII-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Urocortin II, mouse Related Antibodies
In Vivo

Urocortin II, mouse (1-10 μg; icv and i.v.; Adult male Sprague-Dawley rats) induces the expression of Fos[2].
Urocortin II, mouse (1 μg; icv; Adult male Sprague-Dawley rats) is involved in central autonomic nervous system and appetite control[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague-Dawley rats (250-300 g)[2]
Dosage: 1, 5, and 10 μg
Administration: Intracerebroventrical injection and intravenous injection; 1, 5, or 10 μg per animal in 2 μL of saline for i.c.v. injections or 200 μL for i.v. administration
Result: Induced Fos expression in a dose-dependent manner.
Animal Model: Adult male Sprague-Dawley rats (250-300 g)[2]
Dosage: 1 μg
Administration: Intracerebroventrical injection
Result: Reduced food intake over the 12-h interval.
Molecular Weight

4152.96

Formula

C187H320N56O50
CAS No.
Sequence

Val-Ile-Leu-Ser-Leu-Asp-Val-Pro-Ile-Gly-Leu-Leu-Arg-Ile-Leu-Leu-Glu-Gln-Ala-Arg-Tyr-Lys-Ala-Ala-Arg-Asn-Gln-Ala-Ala-Thr-Asn-Ala-Gln-Ile-Leu-Ala-His-Val-NH2
Sequence Shortening

VILSLDVPIGLLRILLEQARYKAARNQAATNAQILAHV-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Urocortin II, mouse Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Urocortin II, mouse330648-32-3CRFRCorticotropin-releasing Factor ReceptorCRHRendogenous peptidemouse ventricular myocytescentral nervous systemdiscrete areavisceral sensory informationInhibitorinhibitorinhibit

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