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Results for "

CT1

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Peptides

15

Recombinant Proteins

12

Antibodies

6

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-168894
    CT-1

    		Ferroptosis JAK STAT p38 MAPK AMPK GSK-3 Apoptosis HSP TNF Receptor Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
    CT-1 is a secreted protein belonging to the IL-6 cytokine family. Overexpression of CT-1 enhances cell proliferation, migration and angiogenesis via the ADMA/DDAH pathway. CT-1 inhibits the growth of triple-negative breast cancer cells by simultaneously inducing Ferroptosis in N2-type tumor-associated neutrophils and cancer cells. CT-1 activates the Jak/STAT-3, p42/p44 MAPK and AMPK pathways, and inhibits GSK-3β activity through phosphorylation to induce cardiomyocyte hypertrophy. CT-1 enhances the viability of cardiomyocytes and neurons, reduces cell Apoptosis, induces the expression of heat shock proteins (HSP) and BNP, and inhibits TNF levels. CT-1 exerts anti-tumor activity in mouse models of triple-negative breast cancer. CT-1 improves cognitive impairment in mice. CT-1 is applicable to the research of ischemic heart disease, triple-negative breast cancer, myocardial hypertrophy, Parkinson's disease, hypertensive heart disease, myocardial infarction, acute Chagas cardiomyopathy, high-fat diet-induced cognitive impairment and diabetes-related cognitive impairment [1] .
    CT-1
  • HY-P10896
    NOTA-P2-RM26

    		Bombesin Receptor Cancer
    NOTA-P2-RM26 is an antagonist of Bombesin (HY-P0195) analogs, and the gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for prostate cancer visualization. NOTA-P2-RM26 is labeled with 111In and 68Ga for prostate cancer imaging studies using PET and SPECT/CT .
    NOTA-P2-RM26
  • HY-150596
    CT1-3

    		Apoptosis Bcl-2 Family JNK Cancer
    CT1-3 is a potent anticancer agent. CT1-3 induces mitochondria-mediated apoptosis by regulating JNK/Bcl-2/Bax/XIAP pathway. CT1-3 suppresses the epithelial mesenchymal transition (EMT) potential of human cancer cells (HCCs) via regulating the E-cadherin/Snail axis, thus inhibits tumorigenesis. CT1-3 has a strong antitumor effect in mice model and exhibits no significant hepatic and renal toxicity [1].
    CT1-3
  • HY-RS13319
    SLC6A8 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SLC6A8 Human Pre-designed siRNA Set A contains three designed siRNAs for SLC6A8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SLC6A8 Human Pre-designed siRNA Set A
    SLC6A8 Human Pre-designed siRNA Set A
  • HY-158220C
    Hyaluronic acid methacryloyl (MW 50000)

    HAMA (MW 50000)

    		 Biochemical Assay Reagents Others
    Hyaluronic acid methacryloyl (HAMA) (MW 50000) is a methacrylate-modified hyaluronic acid that serves as a hydrogel former, hydrolysis-resistant material, photocrosslinkable hydrogel scaffold, and drug delivery carrier for tissue engineering. Hyaluronic acid methacryloyl (MW 50000) forms hydrogels via photocrosslinking; when combined with AuMA NPs through a one-step photocrosslinking method, its effective swelling ratio increases, and the mechanical reinforcement effect of Au NPs compensates for the impact caused by reduced crosslinking density. Hyaluronic acid methacryloyl (MW 50000) can be combined with AuMA NPs via a one-step photocrosslinking method, enabling non-invasive monitoring of hydrogel degradation with contrast-enhanced micro-CT .
    Hyaluronic acid methacryloyl (MW 50000)
  • HY-P10307
    DOTA-ubiquicidin (29–41)

    		Radionuclide-Drug Conjugates (RDCs) Bacterial Infection
    DOTA-ubiquicidin (29-41), an antimicrobial peptide fragment derivative, can be used for synthesis of [ 68Ga]Ga-DOTA-Ubiquicidin29-41 and then used for imaging of infectious processes using PET/CT . DOTA-ubiquicidin (29–41) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    DOTA-ubiquicidin (29–41)
  • HY-W695425
    Creatine transporter-IN-1

    		Amino acid Transporter Cancer
    Creatine transporter-IN-1 is a synthetic creatine transporter (CT1/SLC6A8) inhibitor. Creatine transporter-IN-1 inhibits creatine uptake and shows anticancer activity against cancer cells [1].
    Creatine transporter-IN-1
  • HY-RS03295
    CTF1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CTF1 Human Pre-designed siRNA Set A contains three designed siRNAs for CTF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CTF1 Human Pre-designed siRNA Set A
    CTF1 Human Pre-designed siRNA Set A
  • HY-RS17741
    Ctf1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Ctf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ctf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Ctf1 Mouse Pre-designed siRNA Set A
    Ctf1 Mouse Pre-designed siRNA Set A
  • HY-RS24132
    Slc6a8 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Slc6a8 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc6a8 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Slc6a8 Rat Pre-designed siRNA Set A
    Slc6a8 Rat Pre-designed siRNA Set A
  • HY-RS17671
    Slc6a8 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Slc6a8 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Slc6a8 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Slc6a8 Mouse Pre-designed siRNA Set A
    Slc6a8 Mouse Pre-designed siRNA Set A
  • HY-RS27155
    Slc22a5 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Slc22a5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Slc22a5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Slc22a5 Rat Pre-designed siRNA Set A
    Slc22a5 Rat Pre-designed siRNA Set A
  • HY-115465
    Rev1-CT/RIR PPI-IN-1

    		DNA/RNA Synthesis Cancer
    Rev1-CT/RIR PPI-IN-1 (Compound 1) is a thiophene-based compound. Rev1-CT/RIR PPI-IN-1 can specifically disrupt the protein-protein interaction between Rev1-CT and RIR, with an IC50 value of 2.5 µM. Rev1-CT/RIR PPI-IN-1 can enhance chemosensitivity and reduce the mutation rate in Cisplatin (HY-17394)-sensitive HT-1080 cells. Rev1-CT/RIR PPI-IN-1 can be used for tumor research [1].
    Rev1-CT/RIR PPI-IN-1
  • HY-159803
    IST-622

    6-O-(3-Ethoxypropionyl)-3',4'-O-exo-benzylidenechartreusin

    		 Endogenous Metabolite Cancer
    IST-622 (6-O-(3-Ethoxypropionyl)-3',4'-O-exo-benzylidenechartreusin) is an anti-tumor agent with significant growth inhibitory activity. IST-622 exhibits significant anti-tumor effects against a variety of mouse tumors such as P388 and L1210 leukemias, B16 melanoma, Lewis lung carcinoma, Colon 26 and Colon 38 adenocarcinomas, and M5076 reticulum cell sarcoma. IST-622 was orally administered and the results showed efficacy in different tumor types. In addition, IST-622 provided significant inhibitory effects against two human tumor xenograft models: large cell lung carcinoma (Lu-116) and gastric adenocarcinoma (St-4). IST-622 also exhibited significant growth inhibitory activity against P388 leukemia in vitro, with a half inhibitory concentration (IC50) more than 20 times lower than CT .
    IST-622

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