2. Membrane Transporter/Ion Channel
  3. Amino acid Transporter
  4. Creatine transporter-IN-1

Creatine transporter-IN-1 is a synthetic creatine transporter (CT1/SLC6A8) inhibitor. Creatine transporter-IN-1 inhibits creatine uptake and shows anticancer activity against cancer cells.

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Creatine transporter-IN-1

Creatine transporter-IN-1 Chemical Structure

CAS No. : 1706435-74-6

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Creatine transporter-IN-1 Related Antibodies

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Description

Creatine transporter-IN-1 is a synthetic creatine transporter (CT1/SLC6A8) inhibitor. Creatine transporter-IN-1 inhibits creatine uptake and shows anticancer activity against cancer cells[1].

In Vitro

Creatine transporter-IN-1 (Compound 4) (500 μM) weakly inhibits creatine uptake in CT1-expressing HEK293 cells[1].
Creatine transporter-IN-1 (0.1-100 μM; 24-48 h) reduces the viability of DLD-1 human colorectal adenocarcinoma cells in a concentration-dependent manner[1].
Creatine transporter-IN-1 (0.1-100 μM; 24-72 h) reduces the viability of HT-29 human colorectal adenocarcinoma cells in a concentration-dependent manner[1].
Creatine transporter-IN-1 (0.1-1 mM; 48 h) reduces the viability of MDA-MB-231 human breast adenocarcinoma cells in a concentration-dependent manner at millimolar concentrations[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Creatine transporter-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: human colorectal adenocarcinoma DLD-1 cells
Concentration: 0.1, 1, 10, 50, 100 μM
Incubation Time: 24 h; 48 h
Result: Induced a concentration-dependent decrease in cell viability.
Decreased viability to approximately 80% of control levels at 100 μM after both 24 h and 48 h.
Caused statistically significant reductions at 10, 50, and 100 μM.
Molecular Weight

192.60

Formula

C5H9ClN4O2
CAS No.
SMILES

O=C(C1=CN(CCN)N=N1)O.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Creatine transporter-IN-1 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Creatine transporter-IN-11706435-74-6Amino acid Transporter氨基酸转运蛋白HEK293 cellsDLD-1 human colorectal adenocarcinoma cellsHT-29 human colorectal adenocarcinoma cellscolorectal adenocarcinomaCT1/SLC6A8creatine transporterMDA-MB-231 human breast adenocarcinoma cellsbreast adenocarcinomaInhibitorinhibitorinhibit

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