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Creatine transporter-IN-1

Creatine transporter-IN-1 is a synthetic creatine transporter (CT1/SLC6A8) inhibitor. Creatine transporter-IN-1 inhibits creatine uptake and shows anticancer activity against cancer cells.

For research use only. We do not sell to patients.

CAS No.: 1706435-74-6
Formula: C₅H₉ClN₄O₂
Molecular Weight:192.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Creatine transporter-IN-1 Chemical Structure

CAS No.: 1706435-74-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Creatine transporter-IN-1 is a synthetic creatine transporter (CT1/SLC6A8) inhibitor. Creatine transporter-IN-1 inhibits creatine uptake and shows anticancer activity against cancer cells^[1].

In Vitro

Creatine transporter-IN-1 (Compound 4) (500 μM) weakly inhibits creatine uptake in CT1-expressing HEK293 cells^[1].
Creatine transporter-IN-1 (0.1-100 μM; 24-48 h) reduces the viability of DLD-1 human colorectal adenocarcinoma cells in a concentration-dependent manner^[1].
Creatine transporter-IN-1 (0.1-100 μM; 24-72 h) reduces the viability of HT-29 human colorectal adenocarcinoma cells in a concentration-dependent manner^[1].
Creatine transporter-IN-1 (0.1-1 mM; 48 h) reduces the viability of MDA-MB-231 human breast adenocarcinoma cells in a concentration-dependent manner at millimolar concentrations^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

human colorectal adenocarcinoma DLD-1 cells
Concentration:

0.1, 1, 10, 50, 100 μM
Incubation Time:

24 h; 48 h
Result:

Induced a concentration-dependent decrease in cell viability.
Decreased viability to approximately 80% of control levels at 100 μM after both 24 h and 48 h.
Caused statistically significant reductions at 10, 50, and 100 μM.

Chemical Information

CAS No. 1706435-74-6
Molecular Weight 192.60
Formula C₅H₉ClN₄O₂
SMILES

O=C(C1=CN(CCN)N=N1)O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Stary, Dorota, et al. Structure-Based Search for Novel Creatine Transporter Inhibitors. ACS Medicinal Chemistry Letters (2026).

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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