Creatine transporter-IN-1
Based on 1 Customer Validation
Creatine transporter-IN-1 is a synthetic creatine transporter (CT1/SLC6A8) inhibitor. Creatine transporter-IN-1 inhibits creatine uptake and shows anticancer activity against cancer cells.
For research use only. We do not sell to patients.
- Purity : 98.08%
- CAS No.: 1706435-74-6
- Formula: C5H9ClN4O2
- Molecular Weight:192.60
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Creatine transporter-IN-1 (Compound 4) (500 μM) weakly inhibits creatine uptake in CT1-expressing HEK293 cells[1].
Creatine transporter-IN-1 (0.1-100 μM; 24-48 h) reduces the viability of DLD-1 human colorectal adenocarcinoma cells in a concentration-dependent manner[1].
Creatine transporter-IN-1 (0.1-100 μM; 24-72 h) reduces the viability of HT-29 human colorectal adenocarcinoma cells in a concentration-dependent manner[1].
Creatine transporter-IN-1 (0.1-1 mM; 48 h) reduces the viability of MDA-MB-231 human breast adenocarcinoma cells in a concentration-dependent manner at millimolar concentrations[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human colorectal adenocarcinoma DLD-1 cells
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Concentration:0.1, 1, 10, 50, 100 μM
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Incubation Time:24 h; 48 h
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Result:Induced a concentration-dependent decrease in cell viability.
Decreased viability to approximately 80% of control levels at 100 μM after both 24 h and 48 h.
Caused statistically significant reductions at 10, 50, and 100 μM.
Chemical Information
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CAS No. 1706435-74-6
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Appearance Solid
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Molecular Weight 192.60
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Formula C5H9ClN4O2
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Color Light yellow to yellow
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SMILES
O=C(C1=CN(CCN)N=N1)O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 4.17 mg/mL (21.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.1921 mL | 25.9605 mL | 51.9211 mL | 129.8027 mL |
| 5 mM | 1.0384 mL | 5.1921 mL | 10.3842 mL | 25.9605 mL | |
| 10 mM | 0.5192 mL | 2.5961 mL | 5.1921 mL | 12.9803 mL | |
| 15 mM | 0.3461 mL | 1.7307 mL | 3.4614 mL | 8.6535 mL | |
| 20 mM | 0.2596 mL | 1.2980 mL | 2.5961 mL | 6.4901 mL |
Creatine transporter-IN-1 Related Classifications
HY-W695425 Related Classifications
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Keywords
- Creatine transporter-IN-1
- 1706435-74-6
- Amino acid Transporter
- HEK293 cells
- DLD-1 human colorectal adenocarcinoma cells
- HT-29 human colorectal adenocarcinoma cells
- colorectal adenocarcinoma
- CT1/SLC6A8
- creatine transporter
- MDA-MB-231 human breast adenocarcinoma cells
- breast adenocarcinoma
- Inhibitor
- inhibitor
- inhibit