SLC6A8 Antibody
(Synonyms: Sodium- and chloride-dependent creatine transporter 1, CT1, Creatine transporter 1, Solute carrier family 6 member 8, SLC6A8)SLC6A8 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to SLC6A8.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:50-200 |
Product Details
SLC6A8 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to SLC6A8.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
Synthetic peptide corresponding to the C-term region of human SLC6A8.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
SLC6A8 is a Creatine:sodium symporter which mediates the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity)[1][2][3][4][5][6].
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Subcellular Localization
Cell membrane; Apical cell membrane
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Expression
Tissue_Specificity: Predominantly expressed in skeletal muscle and kidney. Also found in brain, heart, colon, testis and prostate. -
Isoforms & Post-Translational Modification
SLC6A8 has 4 isoforms, P48029-1: amino acid length is 635, molecular weight is 70523 Da (predicted); P48029-2: amino acid length is 732, molecular weight is 80137 Da (predicted); P48029-3: amino acid length is 270, molecular weight is 30580 Da (predicted); P48029-4: amino acid length is 520, molecular weight is 58453 Da (predicted).Glycosylated
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SwissProt ID
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Synonyms
Sodium- and chloride-dependent creatine transporter 1, CT1, Creatine transporter 1, Solute carrier family 6 member 8, SLC6A8
Documentation
[1]. Rosenberg EH, et al. Functional characterization of missense variants in the creatine transporter gene (SLC6A8): improved diagnostic application. Hum Mutat. 2007 Sep;28(9):890-6. [Content Brief]
[2]. Valayannopoulos V, et al. Functional and electrophysiological characterization of four non-truncating mutations responsible for creatine transporter (SLC6A8) deficiency syndrome. J Inherit Metab Dis. 2013 Jan;36(1):103-12. [Content Brief]
[3]. DesRoches CL, et al. Estimated carrier frequency of creatine transporter deficiency in females in the general population using functional characterization of novel missense variants in the SLC6A8 gene. Gene. 2015 Jul 10;565(2):187-91. [Content Brief]
[4]. Sora I, et al. The cloning and expression of a human creatine transporter. Biochem Biophys Res Commun. 1994 Oct 14;204(1):419-27. [Content Brief]
[5]. Nash SR, et al. Cloning, pharmacological characterization, and genomic localization of the human creatine transporter. Recept Channels. 1994;2(2):165-74. [Content Brief]
[6]. Dai W, et al. Molecular characterization of the human CRT-1 creatine transporter expressed in Xenopus oocytes. Arch Biochem Biophys. 1999 Jan 1;361(1):75-84. [Content Brief]
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