Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
Cytochrome-bc1
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "Cytochrome-bc1" in MCE Product Catalog:
4
Target:
Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia [1] .
3
3 Cited Publications
製品番号: HY-B0849
CAS 番号: 131860-33-8
Target:
Environmental Pollutants Reactive Oxygen Species (ROS) Fungal Apoptosis Bacterial Phosphatase
研究分野:
Azoxystrobin is an orally active, broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis [1] .
3
3 Cited Publications
製品番号: HY-N12257
CAS 番号: 27220-57-1
Category:
ELQ-300 is a potent and orally bioavailable antimalarial agent, acts as an inhibitor of the reductive (Qi) site of the cytochrome bc1 complex (cyt bc1). ELQ-300 inhibits growth of P. falciparum Dd2, Tm90-C2B, and D1 with IC50 values of 6.6, 4.6 and 160 nM, respectively. ELQ-300 can be used for the research of antimalarial [1] .
別名: BAS 490 F
研究分野:
Kresoxim-methyl (BAS 490 F), a Strobilurin-based fungicide, inhibits the respiration at the complex III (cytochrome bc1 complex). Kresoxim-methyl binds to complex III from yeast with an apparent Kd of 0.07 μM proving a high affinity for this enzyme [1] .
製品番号: HY-162066
CAS 番号: 2868298-43-3
DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis [1].
製品番号: HY-B0849R
CAS 番号: 131860-33-8
研究分野:
Azoxystrobin (Standard) is the analytical standard of Azoxystrobin. This product is intended for research and analytical applications. Azoxystrobin is a broad-spectrum β-methoxyacrylate fungicide. Azoxystrobin inhibits mitochondrial respiration by binding to the Qo site of the cytochrome bc1 complex and inhibiting electron transfer. Azoxystrobin induces the production of reactive oxygen species (ROS) and induces cell apoptosis.
製品番号: HY-N8540
CAS 番号: 12689-26-8
Category:
Amisulbrom is a sulfonamide fungicide used to control oomycete diseases. Amisulbrom inhibits the cytochrome-bc1 complex of the mitochondrial electron transport system.
製品番号: HY-W715444
CAS 番号: 52110-55-1
Target:
研究分野:
Mucidin is an antifungal antibiotic that inhibits electron-transfer reactions in the cytochrome bc1 complex of the mitochondrial respiratory chain [1].
製品番号: HY-13832R
CAS 番号: 95233-18-4
別名: Atavaquone (Standard)
Atovaquone (Standard) is the analytical standard of Atovaquone. This product is intended for research and analytical applications. Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia [1] .
製品番号: HY-121248
CAS 番号: 67485-29-4
別名: AC217300
Target:
研究分野:
Hydramethylnon (AC217300) is an amidinohydrazone insecticide. Hydramethylnon's mechanism of action is through inhibition of mitochondrial respiration by inhibiting the electron transport chain at the cytochrome b-c1 complex. Hydramethylnon can be used to eliminate red imported fire ants, cockroaches, and other insects [1].
製品番号: HY-121214R
CAS 番号: 348635-87-0
Amisulbrom (Standard) is the analytical standard of Amisulbrom (HY-121214). Amisulbrom is a fungicide. Amisulbrom can inhibit the cytochrome-bc1 complex of the mitochondrial electron and induce mitochondrial dysfunction. Amisulbrom can induce cell apoptosis, ROS production and cause G2/M phase arrest. Amisulbrom shows cardiovascular toxicity to zebrafish. Amisulbrom can be used for the researches of infection and cardiovascular disease [1] .
製品番号: HY-174342
Target:
研究分野:
ELQ-453 is an inhibitor targeting the Qo site of the Plasmodium falciparum cytochrome bc1 complex (CytB) with an IC50 value of 0.57 nM. ELQ-453 blocks the mitochondrial function of the parasite, and suppresses Plasmodium infection in mosquitoes. ELQ-453 is promising for research of malaria [1].
製品番号: HY-172349
CAS 番号: 2059985-55-4
JNJ-2901 is an inhibitor of M. tuberculosis cytochrome bc1:aa3. JNJ-2901 reduces bacterial load in the acute/chronic mouse infection models of M. tuberculosis H37Rv-ΔcydAB. JNJ-2901 can be used in tuberculosis (TB) research [1].
製品番号: HY-156137
CAS 番号: 43152-58-5
Target:
研究分野:
UHDBT is a cytochrome bc1 complex Qo site inhibitor. UHDBT can be used for electron transfer research [1].
製品番号: HY-13832S2
CAS 番号: 1329792-63-3
別名: Atavaquone-d5
製品番号: HY-13834
CAS 番号: 137735-25-2
Target:
研究分野:
GW844520 is an orally active inhibitor of cytochrome bc1 complex. GW844520 can be used in malaria and anti-plasmodium related research [1].
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
