2868298-43-3
Chemical Structure
DNDI-6174
- CAS No.: 2868298-43-3
- Formula:C16H13N5O2
- Molecular Weight:307.31
InChIKey: UFCPCEFCXDROHW-UHFFFAOYSA-N
SMILES: N#CC1=CC=C(C2=C(C)NC3=NC(N)=NC(C)=C32)C4=C1OCO4
Biological Activity: DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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DNDI-6174 | 97.28% | DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis. | ||||||||||||||||||||
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