43 Results for "

D3 ligands

" in MedChemExpress (MCE) Product Catalog:
Products (43)

43 Results for "D3 ligands" in MCE Product Catalog:

14
14 Publications Verification
Cat. No.: HY-32351
CAS No.: 19356-17-3
Synonyms: 25-Hydroxy Vitamin D3
Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
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14
14 Publications Verification
Cat. No.: HY-32351A
CAS No.: 63283-36-3
Synonyms: 25-hydroxy Vitamin D3 monohydrate
Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
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1
1 Cited Publications
Cat. No.: HY-N0368S
CAS No.: 1216673-02-7
Linalool-d3 is the deuterium labeled Linalool . Linalool is natural monoterpene in essential olis of coriander, acts as a competitive antagonist of Nmethyl d-aspartate (NMDA) receptor, with anti-tumor, anti-cardiotoxicity activity .Linalool is a PPARα ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome .
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1 Cited Publications
Cat. No.: HY-12397
CAS No.: 156965-15-0
Purity:  99.23%
Target:  

VD/VDR

Research Areas:  

Endocrinology

ZK159222, a 25-carboxylic ester analogue of 1α,25-(OH)2D3, is a potent 1α,25-(OH)2D3 receptor (VDR) antagonist. The mechanism of ZK159222 antagonistic action is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. ZK159222 has a partial agonistic character .
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1 Cited Publications
Cat. No.: HY-15329
CAS No.: 2070009-38-8
Purity:  99.63%
Maxacalcitol-d66 is the deuterated form of Maxacalcitol (22-Oxacalcitriol), which is a non-calcemic vitamin D3 analog and VDR ligand of VDR-like receptors.
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Cat. No.: HY-32351S
CAS No.: 140710-94-7
Synonyms: 25-Hydroxy Vitamin D3-d3
Calcifediol-d3 is a deuterium labeled Calcifediol. Calcifediol, is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
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Cat. No.: HY-13332
CAS No.: 78782-98-6
Purity:  98.91%
Synonyms: 25-hydroxy Vitamin D3-d6
Calcifediol-d6 is the deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR ligand .
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Cat. No.: HY-B0932S
CAS No.: 1334532-19-2
Synonyms: L-Propionylcarnitine-d3 chloride; ST-261-d3
Levocarnitine propionate-d3 (hydrochloride) is the deuterium labeled Levocarnitine propionate hydrochloride. Levocarnitine propionate hydrochloride (L-Propionylcarnitine chloride; ST-261) is a ligand of carnitine acetyltransferase (CAT) with high enzyme affinity. Levocarnitine propionate hydrochloride possesses antioxidant activity. Levocarnitine propionate hydrochloride increases intracellular L-carnitine reserves. Levocarnitine propionate hydrochloride exerts a protective effect against myocardial ischemia-reperfusion injury. Levocarnitine propionate hydrochloride can be used in research related to myocardial ischemia-reperfusion injury and chronic ischemic heart disease .
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Cat. No.: HY-N10508
CAS No.: 71204-89-2
Calcitroic acid is a water-soluble terminal vitamin D metabolite and also a ligand for vitamin D receptor (VDR). Calcitroic acid binds to the ligand-binding domain of VDR, forms a retinoic X receptor complex, recruits the coactivator peptide MED1, mediates partial VDR-dependent transcription, inhibits Calcitriol (HY-10002)-induced VDR activation, and reduces the transcription level of CYP24A1 in the presence of 1α,25-dihydroxyvitamin D3. Calcitroic acid exerts selective activating effects on VDR, upregulates the expression of CYP24A1 and CYP3A4, decreases the transcription levels of iNOS and IL-1β, reduces the secretion of nitric oxide and IL-1β, and possesses metabolic stability due to its resistance to phase I oxidation and hepatic glucuronidation. Calcitroic acid can be used in research related to colon cancer, inflammatory bowel disease and rickets .
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Cat. No.: HY-N8723S
(1′S,2′S)-Nicotine-1'-oxide-d3 is the d3-labeled (1′S,2′S)-Nicotine-1'-oxide (HY-N8723). (1′S,2′S)-Nicotine-1'-oxide is a nicotine derivative and also a non/weakly potent α3β4 neuronal nicotinic acetylcholine receptor (nAChR) ligand .
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Cat. No.: HY-32351R
CAS No.: 19356-17-3
Synonyms: 25-hydroxy Vitamin D3 (Standard)
Calcifediol (Standard) is the analytical standard of Calcifediol. This product is intended for research and analytical applications. Calcifediol (25-hydroxy Vitamin D3) is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
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Cat. No.: HY-N0927
CAS No.: 483-34-1
Synonyms: Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine
(-)-Isocorypalmine (Tetrahydrocolumbamine; (S)-Tetrahydrocolumbamine) is a dopamine receptor ligand and modulator capable of crossing the blood-brain barrier. (-)-Isocorypalmine exhibits receptor selectivity, acting as a partial agonist of dopamine D1 and D5 receptors (coupled via Gs proteins), as well as an antagonist of D2, D3 and D4 receptors (by blocking Gi protein-mediated signaling). (-)-Isocorypalmine shows no significant binding to various non-dopamine receptors, ion channels and transporters. (-)-Isocorypalmine is metabolically stable in vivo, effectively inhibits spontaneous and cocaine-induced hyperlocomotion, sensitization and conditioned place preference in mice, and does not induce addictive place preference when administered alone. (-)-Isocorypalmine can be used in addiction research .
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Cat. No.: HY-P11035
Target:  

Ephrin Receptor

Research Areas:  

Neurological Disease Cancer

APY-d3 is a highly selective EphA4 receptor inhibitor, with an IC50 value of 17-56 nM for human EphA4, an IC50 value of 20 nM for mouse EphA4, and a Kd value of 138 nM for EphA4-LBD. APY-d3 binds to EphA4, blocks its interaction with ephrin ligands, inhibits tyrosine phosphorylation of EphA4, prevents growth cone collapse, and does not induce EphA4 phosphorylation in primary cortical neurons. APY-d3 adopts a β-hairpin conformation stabilized by an N-terminal to C-terminal disulfide bond. APY-d3 can be used in research related to amyotrophic lateral sclerosis, Alzheimer's disease, stroke, neurodegenerative diseases and cancer .
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Cat. No.: HY-32351AS
CAS No.: 2483831-70-3
Synonyms: 25-hydroxy Vitamin D3-d6 monohydrate
Calcifediol-d6 monohydrate is the deuterium labeled Calcifediol monohydrate. Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), is an effective VDR ligand and VD supplement. Calcifediol is a prohormone of the vitamin D endocrine system (VDES) and is hydroxylated in the liver to produce the active form, calcitriol. Calcifediol can rapidly increase serum VD levels .
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Cat. No.: HY-115953
CAS No.: 2882828-93-3
Target:  

Dopamine Receptor

Research Areas:  

Neurological Disease

Dopamine D3 receptor ligand is a potent, selective and high affinity ligand for Dopamine D3 receptor with 89-fold selective for D3 over D2 (D3 Ki= 8 nM, D2 Ki= 715 nM) .
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Cat. No.: HY-115954
CAS No.: 2882828-95-5
Target:  

Dopamine Receptor

Research Areas:  

Neurological Disease

Dopamine D3 receptor ligand-2 (compound 8) is a potent D3 receptor ligand with a Ki of 11.4 nM. Dopamine D3 receptor ligand-2 have high selectivity for D3 over D2 (Ki=1228 nM) .
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Cat. No.: HY-115955
CAS No.: 2891605-81-3
Target:  

Dopamine Receptor

Research Areas:  

Neurological Disease

Dopamine D3 receptor ligand-3 (compound 12C) is a potent D3 receptor ligand with a Ki of 3.6 nM. Dopamine D3 receptor ligand-3 have high selectivity for D3 over D2 (Ki=353 nM).
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Cat. No.: HY-174307
CAS No.: 687634-09-9
Target:  

Dopamine Receptor

Research Areas:  

Neurological Disease

Dopamine D3 receptor ligand-6 (Compound 196476) is a selective dopamine D3 receptor (D3) antagonist. Dopamine D3 receptor ligand-6 is promising for research of substance use disorders (such as opioid and psychostimulant addiction) .
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Cat. No.: HY-115968
CAS No.: 2376333-77-4
Target:  

Dopamine Receptor

Research Areas:  

Neurological Disease

Dopamine D3 receptor ligand-4 (compound 6) is a potent and selective dopamine D3 receptor ligand, with a Ki of 0.5 nM. Dopamine D3 receptor ligand-4 shows high level of selectivity for D3 over D2 (Ki=7.43 nM) .
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Cat. No.: HY-156239
CAS No.: 2899250-94-1
Research Areas:  

Neurological Disease

Dopamine D3 receptor ligand-5 (13a), a Cariprazine (HY-14763) analogue, is a dopamine D3 receptor ligand, with Ki values of 2.85 nM and 0.14 nM for D2R and D3R, respectively .
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