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Results for "

DCAF15

" in MedChemExpress (MCE) Product Catalog:

14

Inhibitors & Agonists

2

Recombinant Proteins

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13650
    Indisulam
    10+ Cited Publications

    E 7070

    		 Molecular Glues Carbonic Anhydrase Cancer
    Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15 .
    Indisulam
  • HY-14571
    E7820
    5 Publications Verification

    ER68203-00

    		 Molecular Glues Integrin Infection Metabolic Disease Cancer
    E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC50 of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) .
    E7820
  • HY-W037495
    DCAF15 ligand-1

    		Ligands for E3 Ligase Cancer
    DCAF15 ligand-1 (compound 9) is a ligand for the E3 ligase DCAF15. DCAF15 ligand-1 can be used in the synthesis of IBG1 (HY-153459) .
    DCAF15 ligand-1
  • HY-W133627
    dCeMM1

    		Molecular Glues Cancer
    dCeMM1 is a RBM39 glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4 DCAF15 ligase. dCeMM1 decreases the expression of RBM39 levels in WT KBM7 cells .
    dCeMM1
  • HY-153459
    IBG1

    		Molecular Glues Epigenetic Reader Domain Cancer
    IBG1 is a molecular glue degrader targeting BRD2 and BRD4 (DC50: 0.15 nM). IBG1 has no significant degradation effect on its paralogue BRD3. IBG1 can inhibit the growth of cancer cells and can be used in tumor research. (Pink: BRD2/BRD4 Ligand (HY-111139); Black: Linker; Blue: DCAF15 ligand-1 (HY-W037495)) .
    IBG1
  • HY-RS03561
    DCAF15 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    DCAF15 Human Pre-designed siRNA Set A contains three designed siRNAs for DCAF15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    DCAF15 Human Pre-designed siRNA Set A
    DCAF15 Human Pre-designed siRNA Set A
  • HY-177779
    dRRM-1

    		Molecular Glues Cancer
    dRRM-1 is a DCAF15-dependent molecular glue degrader of RBM39 and RBM23. dRRM-1 can rescue the self-degradation of DCAF15. dRRM-1 can be used for the research of cancer .
    dRRM-1
  • HY-RS24784
    Dcaf15 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dcaf15 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dcaf15 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dcaf15 Rat Pre-designed siRNA Set A
    Dcaf15 Rat Pre-designed siRNA Set A
  • HY-RS18306
    Dcaf15 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Dcaf15 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dcaf15 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Dcaf15 Mouse Pre-designed siRNA Set A
    Dcaf15 Mouse Pre-designed siRNA Set A
  • HY-162411
    E3 ligase Ligand 24

    		Ligands for E3 Ligase Cancer
    E3 ligase Ligand 24 (Compound 24) is a Potent Ligand for the E3 Ligase DCAF15 (IC50= 0.053 μM). Due to E3 ligase Ligand 24’s selectivity and potent binding characteristics, it is pivotal in the study of targeted protein degradation .
    E3 ligase Ligand 24
  • HY-149441
    Indisulam analog-1

    		Molecular Glues Cancer
    Indisulam analog-1 (Compound 4) is an analog of Indisulam (HY-13650). Indisulam analog-1 recruits DCAF15-DDB1-DDA1-RBM39 with an EC50 of 1.21 µM. Indisulam analog-1 can be used in the research of colon cancer .
    Indisulam analog-1
  • HY-173274
    CB039

    		Molecular Glues Cancer
    CB039 is a selective a molecular glue degrader that targets RBM39 (RNA-binding protein 39). CB039 promotes the formation of a ternary complex between RBM39 and the E3 ubiquitin ligase CUL4-DCAF15, leading to proteasomal degradation of RBM39. CB039 is promising for research of cancers with RBM39 dependency, such as acute myeloid leukemia (AML) and ovarian cancer .
    CB039
  • HY-13650R
    Indisulam (Standard)

    E 7070 (Standard)

    		 Molecular Glues Carbonic Anhydrase Reference Standards Cancer
    Indisulam (Standard) is the analytical standard of Indisulam. This product is intended for research and analytical applications. Indisulam (E 7070) is a carbonic anhydrase inhibitor with anticancer activity. Indisulam (E 7070) is a sulfonamide agent that targets the G1 phase of the cell cycle. Indisulam (E 7070) causes a blockade in the G1/S transition through inhibition of the activation of both CDK2 and cyclin E. Indisulam (E 7070) targets splicing by inducing RBM39 degradation via recruitment to DCAF15 .
    Indisulam (Standard)
  • HY-183755
    YSA64

    		Molecular Glues Cancer
    YSA64 is an orally active RBM39-targeting molecular glue. YSA64 promotes degradation via formation of a DCAF15/DDB1 ternary complex, dependent on Cullin-RING E3 ligase and proteasome activity. YSA64 can be used for the research of acute myeloid leukemia and Ewing sarcoma .
    YSA64

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