253328-68-6
253328-68-6
Chemical Structure
dRRM-1
- CAS No.: 253328-68-6
- Formula:C16H14N2O2S
- Molecular Weight:298.36
InChIKey: OAKHDXJUOUHIBP-UHFFFAOYSA-N
SMILES: CC1=CC=C(C=C1)S(=O)(NC2=CC=C3N=CC=CC3=C2)=O
Biological Activity: dRRM-1 is a DCAF15-dependent RBM39/RBM23 molecular glue degrader. dRRM-1 stabilizes the interaction between DCAF15 and the novel substrates RBM39 and RBM23, thereby triggering their ubiquitination and degradation. dRRM-1 can be applied in research related to cancer[1][2].
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dRRM-1 | dRRM-1 is a DCAF15-dependent RBM39/RBM23 molecular glue degrader. dRRM-1 stabilizes the interaction between DCAF15 and the novel substrates RBM39 and RBM23, thereby triggering their ubiquitination and degradation. dRRM-1 can be applied in research related to cancer. | |||||||||||||||||||||
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References
- [1]. Hanzl A, et al. E3-Specific Degrader Discovery by Dynamic Tracing of Substrate Receptor Abundance. Journal of the American Chemical Society. 2023 Jan 18;145(2):1176-1184. [Content Brief]
- [2]. Best AJ, et al. High-throughput sensitive screening of small molecule modulators of microexon alternative splicing using dual Nano and Firefly luciferase reporters. Nature communications. 2024 Jul 27;15(1):6328.
