2. PROTAC
  3. Ligands for E3 Ligase
  4. DCAF15 ligand-1

DCAF15 ligand-1 (compound 9) is a ligand for the E3 ligase DCAF15. DCAF15 ligand-1 can be used in the synthesis of IBG1 (HY-153459).

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DCAF15 ligand-1

DCAF15 ligand-1 Chemical Structure

CAS No. : 2098346-67-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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50 mg In-stock
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Based on 1 publication(s) in Google Scholar

DCAF15 ligand-1 Related Antibodies

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1 TRIM21 NEURL1B

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Description

DCAF15 ligand-1 (compound 9) is a ligand for the E3 ligase DCAF15. DCAF15 ligand-1 can be used in the synthesis of IBG1 (HY-153459)[1].

Molecular Weight

340.41

Formula

C17H16N4O2S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=S(C1=CC=C(CN)C=C1)(NC2=CC=C(C)C3=C2NC=C3C#N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (293.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9376 mL 14.6882 mL 29.3763 mL
5 mM 0.5875 mL 2.9376 mL 5.8753 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9376 mL 14.6882 mL 29.3763 mL 73.4408 mL
5 mM 0.5875 mL 2.9376 mL 5.8753 mL 14.6882 mL
10 mM 0.2938 mL 1.4688 mL 2.9376 mL 7.3441 mL
15 mM 0.1958 mL 0.9792 mL 1.9584 mL 4.8961 mL
20 mM 0.1469 mL 0.7344 mL 1.4688 mL 3.6720 mL
25 mM 0.1175 mL 0.5875 mL 1.1751 mL 2.9376 mL
30 mM 0.0979 mL 0.4896 mL 0.9792 mL 2.4480 mL
40 mM 0.0734 mL 0.3672 mL 0.7344 mL 1.8360 mL
50 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4688 mL
60 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2240 mL
80 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9180 mL
100 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
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DCAF15 ligand-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DCAF15 ligand-12098346-67-7Ligands for E3 LigaseE3 ligase-recruiting MoietyanticancerIBG1E3 Ligase ligandInhibitorinhibitorinhibit

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