IBG1
Based on 1 Customer Validation
IBG1 is a molecular glue degrader targeting BRD2 and BRD4 (DC50: 0.15 nM). IBG1 has no significant degradation effect on its paralogue BRD3. IBG1 can inhibit the growth of cancer cells and can be used in tumor research. (Pink: BRD2/BRD4 Ligand (HY-111139); Black: Linker; Blue: DCAF15 ligand-1 (HY-W037495)).
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 2684292-71-3
- Formula: C44H38N8O5S2
- Molecular Weight:822.95
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Epigenetics Compound Library
HY-L005
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Histone Modification Research Compound Library
HY-L024
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Anti-Cancer Compound Library
HY-L025
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Anti-Blood Cancer Compound Library
HY-L079
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Molecular Glue Compound Library
HY-L137
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Anti-Hematopathy Compound Library
HY-L171
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Multi-Target Compound Library
HY-L176
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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BRD2 |
BRD4 0.15 nM (DC50) |
IBG1 (0.1-1000 nM; 6 h) can effectively degrade BRD2 and BRD4 in HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293 cells
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Concentration:0.1, 1, 10, 100, and 1000 nM
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Incubation Time:6 h
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Result:Reduced the levels of BRD2 and BRD4.
Chemical Information
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CAS No. 2684292-71-3
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Appearance Solid
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Molecular Weight 822.95
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Formula C44H38N8O5S2
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Color White to yellow
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SMILES
CC1=C(C)SC2=C1C(C3=CC=C(C4=CC=C(C=C4)C(NCC5=CC=C(C=C5)S(NC6=C7C(C(C#N)=CN7)=C(C=C6)C)(=O)=O)=O)C=C3)=N[C@@H](CC(OC)=O)C8=NN=C(C)N28
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (121.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2151 mL | 6.0757 mL | 12.1514 mL | 30.3785 mL |
| 5 mM | 0.2430 mL | 1.2151 mL | 2.4303 mL | 6.0757 mL | |
| 10 mM | 0.1215 mL | 0.6076 mL | 1.2151 mL | 3.0379 mL | |
| 15 mM | 0.0810 mL | 0.4050 mL | 0.8101 mL | 2.0252 mL | |
| 20 mM | 0.0608 mL | 0.3038 mL | 0.6076 mL | 1.5189 mL | |
| 25 mM | 0.0486 mL | 0.2430 mL | 0.4861 mL | 1.2151 mL | |
| 30 mM | 0.0405 mL | 0.2025 mL | 0.4050 mL | 1.0126 mL | |
| 40 mM | 0.0304 mL | 0.1519 mL | 0.3038 mL | 0.7595 mL | |
| 50 mM | 0.0243 mL | 0.1215 mL | 0.2430 mL | 0.6076 mL | |
| 60 mM | 0.0203 mL | 0.1013 mL | 0.2025 mL | 0.5063 mL | |
| 80 mM | 0.0152 mL | 0.0759 mL | 0.1519 mL | 0.3797 mL | |
| 100 mM | 0.0122 mL | 0.0608 mL | 0.1215 mL | 0.3038 mL |
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