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Pathways Recommended: Cell Cycle/DNA Damage
Results for "

DNA crosslinking agent

" in MedChemExpress (MCE) Product Catalog:

50

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2

Fluorescent Dye

4

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5

Isotope-Labeled Compounds

2

Oligonucleotides

1

GMP Molecules

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-17394
    Cisplatin
    Maximum Cited Publications
    769 Publications Verification

    cis-Platinum; CDDP; cis-Diaminodichloroplatinum

    		 DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase Cancer
    Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .
    Cisplatin
  • HY-B0245
    Busulfan
    15+ Cited Publications

    		 DNA Alkylator/Crosslinker Apoptosis Infection Neurological Disease Inflammation/Immunology Cancer
    Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
    Busulfan
  • HY-W010342
    6-Aminonicotinamide
    15+ Cited Publications

    		 NADPH Oxidase Cancer
    6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP +-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells .
    6-Aminonicotinamide
  • HY-128952
    Tesirine
    5+ Cited Publications

    SG3249

    		 Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker Cancer
    Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
    Tesirine
  • HY-101127
    SGD-1882

    PBD dimer

    		 ADC Payload Cancer
    SGD-1882 is a cytotoxic, DNA minor-groove crosslinking agent pyrrolobenzodiazepine (PBD) dimer, acting as the payload for ADCs.
    SGD-1882
  • HY-101162
    SGD-1910

    		Drug-Linker Conjugates for ADC Cancer
    SGD-1910 is a agent-linker conjugate for ADC by using the antitumor antibiotic, pyrrolobenzodiazepine (PBD, a cytotoxic DNA crosslinking), linked via the cleavable linker MC-Val-Ala .
    SGD-1910
  • HY-14573
    SJG-136
    3 Publications Verification

    NSC-694501

    		 DNA Alkylator/Crosslinker ADC Payload Cancer
    SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity.
    SJG-136
  • HY-B0077
    Bendamustine hydrochloride
    5+ Cited Publications

    SDX-105

    		 DNA Alkylator/Crosslinker Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .
    Bendamustine hydrochloride
  • HY-13567
    Bendamustine
    5+ Cited Publications

    SDX-105 free base

    		 DNA Alkylator/Crosslinker Apoptosis Neurological Disease Inflammation/Immunology Cancer
    Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .
    Bendamustine
  • HY-13543
    Tretazicar

    CB 1954

    		 Quinone Reductase DNA Alkylator/Crosslinker Cancer
    Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .
    Tretazicar
  • HY-111397
    Bizelesin
    1 Publications Verification

    NSC 615291; U-77779

    		 DNA Alkylator/Crosslinker Cancer
    Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity .
    Bizelesin
  • HY-13703A
    Nimustine hydrochloride
    1 Publications Verification

    ACNU

    		 DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis p38 MAPK JNK AP-1 Cancer
    Nimustine hydrochloride (ACNU) is the hydrochloride salt form of Nimustine (HY-13703). Nimustine hydrochloride is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine hydrochloride activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity .
    Nimustine hydrochloride
  • HY-B0245S
    Busulfan-d8

    		DNA Alkylator/Crosslinker Apoptosis Inflammation/Immunology Cancer
    Busulfan-d8 is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
    Busulfan-d8
  • HY-126539
    UBE2T/FANCL-IN-1
    1 Publications Verification

    		 E1/E2/E3 Enzyme Cancer
    UBE2T/FANCL-IN-1 is a potent inhibitor of UBE2T/FANCL-mediated FANCD2 monoubiquitylation that sensitizes cells to the DNA cross-linking agent, Carboplatin .
    UBE2T/FANCL-IN-1
  • HY-139621
    Colibactin 742

    		DNA Alkylator/Crosslinker Cancer
    Colibactin 742 is a covalently binding DNA-damaging agent targeting DNA, with an IC50 of 5.2 μM against human cervical cancer cells (HeLa). Colibactin 742 covalently binds to DNA, forming interstrand crosslinks (ICLs), activating the Fanconi anemia DNA repair pathway, inducing γH2AX and FANCD2 foci formation and cell cycle arrest, while exacerbating mismatch repair deficiency (MMRd)-related mutations. Colibactin 742 can mimic the genotoxicity of natural Colibactin while avoiding its instability, and is mainly used in colorectal cancer (CRC) related research, including microbial tumorigenesis mechanisms, DNA damage repair pathways, and mutation signature analysis .
    Colibactin 742
  • HY-B0245R
    Busulfan (Standard)

    		DNA Alkylator/Crosslinker Apoptosis Reference Standards Inflammation/Immunology Cancer
    Busulfan (Standard) is the analytical standard of Busulfan. This product is intended for research and analytical applications. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .
    Busulfan (Standard)
  • HY-16405
    PR-104

    		DNA Alkylator/Crosslinker Cancer
    PR-104 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A .
    PR-104
  • HY-W781133
    cDPCP

    cis-[Pt(NH3)2N1-pyridineCl]Cl

    		 DNA Alkylator/Crosslinker Cancer
    cDPCP (cis-[Pt(NH3)2(N1-pyridine)Cl]Cl) is a DNA crosslinking agent and also a substrate for OCT1 and OCT2. DPCP exhibits anticancer activity and can improve the survival rate of sarcoma-180 mice. cDPCP is suitable for the research of colorectal cancer and cancers with appropriate cation transporters .
    cDPCP
  • HY-W075885
    trans-Platinum(II)diammine dichloride

    trans-platinumdiamminedichloride

    		 DNA Alkylator/Crosslinker Others
    trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links .
    trans-Platinum(II)diammine dichloride
  • HY-14572
    PR-104A

    SN 27858

    		 DNA Alkylator/Crosslinker Drug Metabolite Cancer
    PR-104A (SN 27858) is the alcohol metabolite of phosphate proagent PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity . PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL) .
    PR-104A
  • HY-W341499
    5-Formyl-2'-deoxyuridine

    		Endogenous Metabolite Others
    5-Formyl-2'-deoxyuridine is a product formed when the 5-methyl group of thymine in DNA undergoes oxidation due to exposure to gamma radiation or certain chemical agents. Serving as a biomarker of oxidative DNA damage, 5-formyl-2'-deoxyuridine is employed in investigations of DNA damage and repair mechanisms. Additionally, 5-Formyl-2'-deoxyuridine can be used in studies involving chemically crosslinking with peptides derived from the RecA protein .
    5-Formyl-2'-deoxyuridine
  • HY-W111005
    1-Chloromethylpyrene

    		DNA Alkylator/Crosslinker Cancer
    1-Chloromethylpyrene is an alkylating agent that enters the DNA double helix structure through intercalation, forms covalent bonds with electrophilic groups, resulting in DNA cross-linking, thereby inhibiting the proliferation of tumor cells .
    1-Chloromethylpyrene
  • HY-402091
    SJG-136 intermediate-1

    		ADC Payload Others
    SJG-136 intermediate-1 (compound 19) is an intermediate for synthesizing SJG-136. SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA .
    SJG-136 intermediate-1
  • HY-W007712
    2-Bromo-3-methylpyridine
    1 Publications Verification

    2-Bromo-3-picoline

    		 Drug Intermediate Cancer
    2-Bromo-3-methylpyridine (2-Bromo-3-picoline) is a heterocyclic intermediate of the halomethylpyridine family. 2-Bromo-3-methylpyridine can be used in the synthesis of platinum(IV) diazide complexes .
    2-Bromo-3-methylpyridine
  • HY-114577
    Palifosfamide tromethamine
    2 Publications Verification

    Isophosphoramide mustard tromethamine; IPM tromethamine; ZIO-201 tromethamine

    		 DNA Alkylator/Crosslinker Cancer
    Palifosfamide (tromethamine) is a synthetic alkylating agent with potential antineoplastic activity. As the stabilized active metabolite of ifosfamide, palifosfamide (tromethamine) irreversibly alkylates and crosslinks DNA through GC base pairs. This leads to an inhibition of DNA replication and ultimately cell death. Compared to ifosfamide, palifosfamide (tromethamine) is less toxic.
    Palifosfamide tromethamine
  • HY-D2438
    CDDP-PEG-Cy3

    		Fluorescent Dye Cancer
    CDDP-PEG-Cy3 is a CDDP-PEG conjugate labeled with Cy3 (HY-D0822). The Cy3 fluorophore is commonly used in applications such as immunolabeling, nucleic acid labeling, fluorescence microscopy, and flow cytometry. The maximum emission wavelength of Cy3 is approximately 562-570 nm. Cisplatin (CDDP) (HY-17394) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .
    CDDP-PEG-Cy3
  • HY-U00265
    3-CPs

    3-Carbethoxypsoralen; 3-Ethoxycarbonylpsoralen

    		 Bacterial Infection
    3-CPs is a monofunctional furanocoumarin and a photoprotective agent targeting Staphylococcus aureus DNA, possessesing anti-UVB lethal activity. 3-CPs competitively intercalates into DNA, forming exclusively 4',5'-furan-side mono-adducts upon UVB irradiation, and irreversibly inhibits the formation of cyclobutane pyrimidine dimers. 3-CPs prevents UVB-induced DNA damage by preferentially binding to strong (AT)n sites within the DNA, without inducing lethal interstrand DNA cross-links; the limited number of mono-adducts it induces can be efficiently repaired by bacteria. 3-CPs holds potential for use in the development of photoprotective formulations for skin diseases, as well as in studies investigating bacterial DNA photodamage repair mechanisms and the optimization of photochemotherapy safety .
    3-CPs
  • HY-13703
    Nimustine

    		Apoptosis DNA Alkylator/Crosslinker DNA/RNA Synthesis p38 MAPK JNK AP-1 Cancer
    Nimustine is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity .
    Nimustine
  • HY-W010342R
    6-Aminonicotinamide (Standard)

    		NADPH Oxidase Reference Standards Cancer
    6-Aminonicotinamide, a potent antimetabolite of nicotinamide, is competitive NADP+-dependent enzyme glucose-6-phosphate dehydrogenase (G6PD) inhibitor (Ki=0.46 μM). 6-Aminonicotinamide resultis ATP depletion and synergizes with DNA-crosslinking chemotherapy agents, such as Cisplatin (HY-17394), in killing cancer cells .
    6-Aminonicotinamide (Standard)
  • HY-164401
    QBS10072S

    		EAAT DNA/RNA Synthesis DNA Alkylator/Crosslinker Neurological Disease Cancer
    QBS10072S is a bifunctional chemotherapeutic agent that can cross the blood-brain barrier (BBB), comprising a LAT1-targeting domain and a cytotoxic domain. QBS10072S exhibits inhibitory potency against LAT1-mediated substrate uptake (IC50 = 21 μM) of approximately 50-fold higher than that against LAT2 (IC50 = 1100 μM). QBS10072S enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces DNA interstrand crosslinking, and causes DNA damage and cell death. QBS10072S can be used for the research of glioblastoma and aggressive T-cell lymphoma .
    QBS10072S
  • HY-128952G
    Tesirine

    SG3249

    		 Drug-Linker Conjugates for ADC DNA Alkylator/Crosslinker Cancer
    Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
    Tesirine
  • HY-139635
    Anticancer agent 11

    		DNA Alkylator/Crosslinker Cancer
    Anticancer agent 11 is a broad-spectrum anticancer agent that inhibits angiogenesis and induces DNA cross-links.
    Anticancer agent 11
  • HY-13567S
    Bendamustine-d4

    SDX-105 D4 free base

    		 Isotope-Labeled Compounds DNA Alkylator/Crosslinker Cancer
    Bendamustine-d4 is the deuterium labeled Bendamustine. Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties.
    Bendamustine-d4
  • HY-402090
    SJG-136 intermediate-2

    		ADC Payload Others
    SJG-136 intermediate-2 (compound 141) is an intermediate for synthesizing SJG-136. SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA .
    SJG-136 intermediate-2
  • HY-B0077S1
    Bendamustine-d8 hydrochloride

    SDX-105-d8

    		 Isotope-Labeled Compounds DNA Alkylator/Crosslinker Apoptosis Cancer
    Bendamustine-d8 (hydrochloride) is deuterium labeled Bendamustine (hydrochloride). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .
    Bendamustine-d8 hydrochloride
  • HY-13567S1
    Bendamustine-d8

    SDX-105-d8 free base

    		 DNA Alkylator/Crosslinker Apoptosis Cancer
    Bendamustine-d8 is the deuterium labeled Bendamustine . Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .
    Bendamustine-d8
  • HY-B0077R
    Bendamustine hydrochloride (Standard)

    SDX-105 (Standard)

    		 Reference Standards DNA Alkylator/Crosslinker Apoptosis Cancer
    Bendamustine (hydrochloride) (Standard) is the analytical standard of Bendamustine (hydrochloride). This product is intended for research and analytical applications. Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .
    Bendamustine hydrochloride (Standard)
  • HY-13567R
    Bendamustine (Standard)

    SDX-105 free base (Standard)

    		 DNA Alkylator/Crosslinker Apoptosis Reference Standards Cancer
    Bendamustine (Standard) is the analytical standard of Bendamustine. This product is intended for research and analytical applications. Bendamustine (SDX-105 free base), a purine analogue, is a DNA cross-linking agent. Bendamustine activates DNA-damage stress response and apoptosis. Bendamustine has potent alkylating, anticancer and antimetabolite properties .
    Bendamustine (Standard)
  • HY-147740
    WEHI-150

    		DNA Alkylator/Crosslinker Cancer
    WEHI-150 is a replica of mitoxantrone, is a portent DNA interstrand crosslinkagent with an adduct half-lives of 12.5 h. WEHI-150 forms covalent adducts at CpG sequences and exhibits a preference for methylated CpG sites. Formaldehyde-activated WEHI-150 induces DNA interstrand crosslinks. Formaldehyde-activated WEHI-150 shows Concentration-dependent transcription blockages. WEHI-150 can mediate covalent adducts that are independent of interactions with the N-2 of guanine and is capable of adduct formation at novel DNA sequences .
    WEHI-150
  • HY-117909
    CEP-40125

    RXDX-107

    		 Apoptosis Cancer
    CEP-40125 (RXDX-107) is a modified form of Bendamustine (HY-13567), a DNA cross-linking agent that may cause DNA damage and cell apoptosis. CEP-40125 (RXDX-107) is formed by encapsulating the alkyl ester form of Bendamustine in human serum albumin .
    CEP-40125
  • HY-W738282
    Bendamustine-d7 hydrochloride

    SDX-105-d7

    		 Isotope-Labeled Compounds DNA Alkylator/Crosslinker Apoptosis Cancer
    Bendamustine-d7 hydrochloride (SDX-105-d7) is the deuterium labeled Bendamustine hydrochloride (HY-B0077). Bendamustine hydrochloride (SDX-105), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride activats DNA-damage stress response and apoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties .
    Bendamustine-d7 hydrochloride
  • HY-106109
    FK 973

    		DNA Alkylator/Crosslinker DNA/RNA Synthesis Cancer
    FK 973 is a dihydrobenzoxazine anticancer agent. FK 973 selectively inhibits DNA synthesis and can form DNA cross-links through cytoplasmic activation. FK 973 exhibits significant antitumor activity in various animal tumor models and human tumor xenografts, with relatively weak myelosuppressive effects. FK 973 is sensitive to neural tumor cells. FK 973 can be used for DNA-targeted antitumor research .
    FK 973
  • HY-16406
    PR-104 sodium

    		DNA Alkylator/Crosslinker Cancer
    PR-104 (sodium) is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104 (sodium), as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A .
    PR-104 sodium
  • HY-13543R
    Tretazicar (Standard)

    CB 1954 (Standard)

    		 DNA Alkylator/Crosslinker Reference Standards Cancer
    Tretazicar (Standard) is the analytical standard of Tretazicar. This product is intended for research and analytical applications. Tretazicar (CB 1954), an antitumor proagent, is highly selective against the Walker 256 rat tumour line. Tretazicar is enzymatically activated to generate a bifunctional agent, which can form DNA-DNA interstrand cross-links. Tretazicar in rat cells involves the reduction of its 4-nitro group to a 4-hydroxylamine by the enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1) .
    Tretazicar (Standard)
  • HY-18774
    Cycloplatam

    		DNA Alkylator/Crosslinker Cancer
    Cycloplatam is a DNA crosslinking agent. Cycloplatam inhibits tumor cell DNA replication and transcription. Cycloplatam is promising for research of ovarian cancer, lung cancer, and other solid tumors .
    Cycloplatam
  • HY-13567A
    Bendamustine hydrochloride hydrate

    SDX-105 hydrate

    		 DNA Alkylator/Crosslinker Apoptosis Metabolic Disease
    Bendamustine hydrochloride hydrate (SDX-105 hydrate), a purine analogue, is a DNA cross-linking agent. Bendamustine hydrochloride hydrate activates DNA-damage stress response and apoptosis. Bendamustine hydrochloride hydrate has potent alkylating, anticancer and antimetabolite properties .
    Bendamustine hydrochloride hydrate
  • HY-W075885R
    trans-Platinum(II)diammine dichloride (Standard)

    trans-platinumdiamminedichloride (Standard)

    		 Biochemical Assay Reagents Reference Standards Others
    trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) (Standard) is an analytical standard for trans-Platinum(II)diammine dichloride (HY-W075885). This product is intended for research and analytical applications. trans-Platinum(II)diammine dichloride is a geometric isomer of Cisplatin (HY-17394). trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage but exhibits low cytotoxicity. trans-Platinum(II)diammine dichloride can be used to study DNA-protein cross-links.
    trans-Platinum(II)diammine dichloride (Standard)
  • HY-185389
    Cisplatin liposome

    Liposomal cisplatin

    		 Liposome DNA Alkylator/Crosslinker Cancer
    Cisplatin liposome is a liposome-encapsulated form of Cisplatin (HY-17394). Cisplatin (CDDP) is an anti-tumor chemotherapeutic agent that cross-links with DNA, causing DNA damage in cancer cells. Cisplatin liposome prolongs drug circulation time and slowly releases the drug, allowing it to accumulate in the tumor and exert its killing effect.
    Cisplatin liposome
  • HY-132974
    Aminoflavone

    NSC-686288

    		 Aryl Hydrocarbon Receptor Reactive Oxygen Species (ROS) DNA Alkylator/Crosslinker DNA/RNA Synthesis Caspase Apoptosis HIF/HIF Prolyl-Hydroxylase Cancer
    Aminoflavone is an anti-tumor agent. Aminoflavone inhibits the expression of ITGA6/SOX2 by activating the AhR-miR-125b-2-3p axis, thereby targeting breast cancer stem cells. Aminoflavone induces an increase in intracellular ROS, increases the level of oxidative DNA damage marker 8-oxodG and DNA-protein cross-links. Aminoflavone causes S-phase arrest, activates caspase-3/8/9 and induces apoptosis (apoptosis). Aminoflavone inhibits HIF-1α expression in a manner independent of AhR. Aminoflavone can be used for the study of breast cancer .
    Aminoflavone
  • HY-164401A
    QBS10072S dihydrochloride

    		EAAT DNA/RNA Synthesis DNA Alkylator/Crosslinker Neurological Disease Cancer
    QBS10072S dihydrochloride is a bifunctional chemotherapeutic agent that can cross the blood-brain barrier (BBB), comprising a LAT1-targeting domain and a cytotoxic domain. QBS10072S dihydrochloride exhibits inhibitory potency against LAT1-mediated substrate uptake (IC50 = 21 μM) of approximately 50-fold higher than that against LAT2 (IC50 = 1100 μM). QBS10072S dihydrochloride enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces DNA interstrand crosslinking, and causes DNA damage and cell death. QBS10072S dihydrochloride can be used for the research of glioblastoma and aggressive T-cell lymphoma .
    QBS10072S dihydrochloride

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