129655-21-6
Chemical Structure
Bizelesin
Synonym(s): NSC 615291; U-77779
- CAS No.: 129655-21-6
- Formula:C43H36Cl2N8O5
- Molecular Weight:815.70
IUPAC Name: 1,3-bis(2-((S)-1-(chloromethyl)-5-hydroxy-8-methyl-1,2,3,6-tetrahydropyrrolo[3,2-e]indole-3-carbonyl)-1H-indol-5-yl)urea
InChIKey: FONKWHRXTPJODV-DNQXCXABSA-N
SMILES: O=C(NC1=CC2=C(NC(C(N3C4=CC(O)=C5NC=C(C)C5=C4[C@H](CCl)C3)=O)=C2)C=C1)NC6=CC7=C(NC(C(N8C9=CC(O)=C%10NC=C(C)C%10=C9[C@H](CCl)C8)=O)=C7)C=C6
Biological Activity: Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity[1].
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Bizelesin | 95.07% | Bizelesin (NSC 615291; U-77779) is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity. | ||||||||||||||||||||
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Keywords